ArticleGenetics2011
Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 254 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
254 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Declining autozygosity over time: An exploration in over 1 million individuals from three diverse cohorts.American journal of human genetics · 2023Pooled it
- Pooled it
- Associations of autozygosity with a broad range of human phenotypes.Nature communications · 2019Pooled it
- Limited Lifetime Costs of Inbreeding in a Large Wild Population of Superb Fairy-Wrens.Molecular ecology · 2026Article
- Genome-wide SNP-based genomic diversity and population structure analysis in alpaca populations from Europe and Peru.G3 (Bethesda, Md.) · 2026Article
- Unique Population or Unique Species? Genetic Insights Into the Pygmy Freshwater Crocodiles of Northern Australia.Ecology and evolution · 2026Article
- Is Blood Thicker Than Water? The Influence of Kin Within a Bull Shark Social Network.Ecology and evolution · 2026Article
- Genomic partitioning and functional dissection of inbreeding depression for stature in Brown Swiss cattle.Genetics, selection, evolution : GSE · 2026Article
- An analysis of the genomic architecture of the worldwide Irish Wolfhound dogs.Scientific reports · 2026Article
- Mothers Matter Most: Maternal, but Not Paternal, Age and Inbreeding Affect Nestling Telomere Length in a Wild Passerine.Molecular ecology · 2026Article
- Population Structure Analysis and Candidate Gene Screening for Twinning Trait in Simmental Cattle.Animals : an open access journal from MDPI · 2026Article
- Article
- Genomic insights into the admixture and diversity of Kerala crossbred cattle.Scientific reports · 2026Article
- Review
- No Pedigree, No Problem: Genomic Inbreeding Tracks Genetic Rescue With High Resolution.Evolutionary applications · 2026Article
- Probabilities of two alleles being identity by state at unobserved loci predicted by observed loci in cattle populations.Scientific reports · 2026Article
- Genomic prediction for grain yield and biotic stress resistance in field pea (Frontiers in plant science · 2026Article
- Genomic Architecture of Inbreeding Depression Associated With Hatching Failure in an Endangered Parrot.Molecular ecology · 2026Article
- Analysis of Inbreeding Coefficient and Genetic Diversity in Xinjiang Brown Cattle Based on Pedigree and ROH Evaluation.Animals : an open access journal from MDPI · 2025Article
- Genomic scans for diversity and selection signatures in Indian Red Sindhi cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
194 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
Abstract
Inbreeding depression, which refers to reduced fitness among offspring of related parents, has traditionally been studied using pedigrees. In practice, pedigree information is difficult to obtain, potentially unreliable, and rarely assessed for inbreeding arising from common ancestors who lived more than a few generations ago. Recently, there has been excitement about using SNP data to estimate inbreeding (F) arising from distant common ancestors in apparently "outbred" populations. Statistical power to detect inbreeding depression using SNP data depends on the actual variation in inbreeding in a population, the accuracy of detecting that with marker data, the effect size, and the sample size. No one has yet investigated what variation in F is expected in SNP data as a function of population size, and it is unclear which estimate of F is optimal for detecting inbreeding depression. In the present study, we use theory, simulated genetic data, and real genetic data to find the optimal estimate of F, to quantify the likely variation in F in populations of various sizes, and to estimate the power to detect inbreeding depression. We find that F estimated from runs of homozygosity (Froh), which reflects shared ancestry of genetic haplotypes, retains variation in even large populations (e.g., SD=0.5% when Ne=10,000) and is likely to be the most powerful method of detecting inbreeding effects from among several alternative estimates of F. However, large samples (e.g., 12,000-65,000) will be required to detect inbreeding depression for likely effect sizes, and so studies using Froh to date have probably been underpowered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.