ArticleEukaryotic cell2011
Endosomal localization of the serum resistance-associated protein in African trypanosomes confers human infectivity.
Article in Eukaryotic cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Pseudokinase NRP1 facilitates endocytosis of transferrin in the African trypanosome.Scientific reports · 2022Article
- Kidney disease and APOL1.Human molecular genetics · 2021Review
- Sustainable Elimination (Zero Cases) of Sleeping Sickness: How Far Are We from Achieving This Goal?Pathogens (Basel, Switzerland) · 2019Review
- APOL1: The Balance Imposed by Infection, Selection, and Kidney Disease.Trends in molecular medicine · 2018Review
- Review
- The structure of serum resistance-associated protein and its implications for human African trypanosomiasis.Nature microbiology · 2018Article
- Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1.PLoS pathogens · 2018Article
- The Cell Biology of APOL1.Seminars in nephrology · 2017Review
- APOL1 variants change C-terminal conformational dynamics and binding to SNARE protein VAMP8.JCI insight · 2017Article
- Controlling transferrin receptor trafficking with GPI-valence in bloodstream stage African trypanosomes.PLoS pathogens · 2017Article
- Sending a message: extracellular vesicles of pathogenic protozoan parasites.Nature reviews. Microbiology · 2016Review
- A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense.PLoS neglected tropical diseases · 2016Article
- Apolipoprotein L1 and Kidney Disease in African Americans.Trends in endocrinology and metabolism: TEM · 2016Review
- Article
- An Overview ofFrontiers in microbiology · 2016Review
- Localization of serum resistance-associated protein in Trypanosoma brucei rhodesiense and transgenic Trypanosoma brucei brucei.Cellular microbiology · 2015Article
- BH3 domain-independent apolipoprotein L1 toxicity rescued by BCL2 prosurvival proteins.American journal of physiology. Cell physiology · 2015Article
- APOL1 genetic variants, chronic kidney diseases and hypertension in mixed ancestry South Africans.BMC genetics · 2015Article
- Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: relevance to trypanosome lysis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Trypanosoma brucei rhodesiense is the causative agent of human African sleeping sickness. While the closely related subspecies T. brucei brucei is highly susceptible to lysis by a subclass of human high-density lipoproteins (HDL) called trypanosome lytic factor (TLF), T. brucei rhodesiense is resistant and therefore able to establish acute and fatal infections in humans. This resistance is due to expression of the serum resistance-associated (SRA) gene, a member of the variant surface glycoprotein (VSG) gene family. Although much has been done to establish the role of SRA in human serum resistance, the specific molecular mechanism of SRA-mediated resistance remains a mystery. Thus, we report the trafficking and steady-state localization of SRA in order to provide more insight into the mechanism of SRA-mediated resistance. We show that SRA traffics to the flagellar pocket of bloodstream-form T. brucei organisms, where it localizes transiently before being endocytosed to its steady-state localization in endosomes, and we demonstrate that the critical point of colocalization between SRA and TLF occurs intracellularly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.