ArticleGenome biology and evolution2011
Characterizing the influence of effective population size on the rate of adaptation: Gillespie's Darwin domain.
Article in Genome biology and evolution, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed.
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- Recombination Suppression Drives Expansion of the Drosophila Dot Chromosome.Molecular biology and evolution · 2025Article
- Adapting to climate with limited genetic diversity: Nucleotide, DNA methylation and microbiome variation among populations of the social spider Stegodyphus dumicola.Molecular ecology · 2022Article
- What Drives Caterpillar Guilds on a Tree: Enemy Pressure, Leaf or Tree Growth, Genetic Traits, or Phylogenetic Neighbourhood?Insects · 2022Article
- Land use and life history constrain adaptive genetic variation and reduce the capacity for climate change adaptation in turtles.BMC genomics · 2021Article
- Molecular population genetics of Sex-lethal (Sxl) in the Drosophila melanogaster species group: a locus that genetically interacts with Wolbachia pipientis in Drosophila melanogaster.G3 (Bethesda, Md.) · 2021Article
- How Much DoesGenetics · 2020Article
- Adaptive Introgression across Semipermeable Species Boundaries between Local Helicoverpa zea and Invasive Helicoverpa armigera Moths.Molecular biology and evolution · 2020Article
- Population genomics of Vibrionaceae isolated from an endangered oasis reveals local adaptation after an environmental perturbation.BMC genomics · 2020Article
- Is adaptation limited by mutation? A timescale-dependent effect of genetic diversity on the adaptive substitution rate in animals.PLoS genetics · 2020Article
- Dissecting the Effects of Selection and Mutation on Genetic Diversity in Three Wood White (Leptidea) Butterfly Species.Genome biology and evolution · 2019Article
- Paternally Expressed Imprinted Genes under Positive Darwinian Selection in Arabidopsis thaliana.Molecular biology and evolution · 2019Article
- Expansion history and environmental suitability shape effective population size in a plant invasion.Molecular ecology · 2019Article
- Comparative transcriptomics sheds light on differential adaptation and species diversification between twoAoB PLANTS · 2019Article
- Pleiotropy Modulates the Efficacy of Selection in Drosophila melanogaster.Molecular biology and evolution · 2019Article
- Identifying consistent allele frequency differences in studies of stratified populations.Methods in ecology and evolution · 2017Article
- Determinants of the Efficacy of Natural Selection on Coding and Noncoding Variability in Two Passerine Species.Genome biology and evolution · 2017Article
- Genomic changes following the reversal of a Y chromosome to an autosome in Drosophila pseudoobscura.Evolution; international journal of organic evolution · 2017Article
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2 authors.
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Abstract
Characterizing the role of effective population size in dictating the rate of adaptive evolution remains a major challenge in evolutionary biology. Depending on the underlying distribution of fitness effects of new mutations, populations of different sizes may differ vastly in their rate of adaptation. Here, we collect polymorphism data at over 100 loci for two closely related Drosophila species with different current effective population sizes (N(e)), Drosophila miranda and D. pseudoobscura, to evaluate the prevalence of adaptive evolution versus genetic drift in molecular evolution. Utilizing these large and consistently sampled data sets, we obtain greatly improved estimates of the demographic histories of both species. Specifically, although current N(e) differs between these species, their ancestral sizes were much more similar. We find that statistical approaches capturing recent adaptive evolution (using patterns of polymorphisms) detect higher rates of adaptive evolution in the larger D. pseudoobscura population. In contrast, methods aimed at detecting selection over longer time periods (i.e., those relying on divergence data) estimate more similar rates of adaptation between the two species. Thus, our results suggest an important role of effective population size in dictating rates of adaptation and highlight how complicated population histories--as is probably the case for most species--can effect rates of adaptation. Additionally, we also show how different methodologies to detect positive selection can reveal information about different timescales of adaptive evolution.
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