Evidence map›Paper›PMID 21704981›Full record

ArticleBrain research2011

Removal of polysialylated neural cell adhesion molecule increases morphine analgesia and interferes with tolerance in mice.

Abderrahman El Maarouf, Yuri Kolesnikov, Gavril Pasternak, Urs Rutishauser

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Abderrahman El MaaroufDepartment of Cell Biology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. a-el-maarouf@ski.mskcc.org
Yuri Kolesnikov
Gavril Pasternak
Urs Rutishauser

Funding

PHARMACOLOGY OF OPIOID RECEPTOR SUBTYPESR01DA007242 · NIDA · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI PAN, YING-XIAN · 1991 to 2022
$6.0M
NIDA NIH HHS R01 DA007242
6 · The paper itself

Abstract

Neurons that express high levels of polysialylated neural cell adhesion molecule (PSA-NCAM) in adult spinal substantia gelatinosa also express the μ-opioid receptor. While PSA removal from NCAM by spinal intrathecal injection of endoneuraminidase-N (endo-N) did not detectably change opioid receptor expression, morphine-induced analgesia was significantly increased. This analgesic strengthening was detected as early as 15 min after endo-N treatment and persisted for at least 7 days. In addition, the tolerance that develops with chronic morphine treatment was overcome in the absence of PSA. Interestingly, the same effects on analgesia and tolerance were also produced by selective deletion of the NCAM-180 isoform.

Indexed as

Analgesics, OpioidAnimalsBehavior, AnimalDrug InteractionsDrug ToleranceGene Expression RegulationGlycoside HydrolasesMaleMiceMice, KnockoutMorphineNeural Cell Adhesion Molecule L1Neural Cell Adhesion MoleculesPain MeasurementReceptors, Opioid, muSialic AcidsAnalgesics, Opioidendo-alpha-sialidaseGlycoside HydrolasesMorphineNeural Cell Adhesion Molecule L1Neural Cell Adhesion Moleculespolysialyl neural cell adhesion moleculeReceptors, Opioid, muSialic Acids

Identifiers

PMID21704981
PMCPMC4041115

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.