ArticleMolecular immunology2011
Expression of duck CCL19 and CCL21 and CCR7 receptor in lymphoid and influenza-infected tissues.
Article in Molecular immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Tissue Specific Transcriptome Changes Upon Influenza A Virus Replication in the Duck.Frontiers in immunology · 2021Article
- Article
- Ducks induce rapid and robust antibody responses than chickens at early time after intravenous infection with H9N2 avian influenza virus.Virology journal · 2019Article
- Innate Immune Responses to Avian Influenza Viruses in Ducks and Chickens.Veterinary sciences · 2019Review
- Comparative analysis of virus-host interactions caused by a virulent and an attenuated duck hepatitis A virus genotype 1.PloS one · 2017Article
- A Panel of Stably Expressed Reference Genes for Real-Time qPCR Gene Expression Studies of Mallards (Anas platyrhynchos).PloS one · 2016Article
- Duck TRIM27-L enhances MAVS signaling and is absent in chickens and turkeys.Molecular immunology · 2015Article
- Defense genes missing from the flight division.Developmental and comparative immunology · 2013Review
- Interspecies transmission and emergence of novel viruses: lessons from bats and birds.Trends in microbiology · 2013Review
- Differential cellular gene expression in duck trachea infected with a highly or low pathogenic H5N1 avian influenza virus.Virology journal · 2013Article
- Identification of avian RIG-I responsive genes during influenza infection.Molecular immunology · 2013Article
- Transcriptional analysis of the innate immune response of ducks to different species-of-origin low pathogenic H7 avian influenza viruses.Virology journal · 2013Article
- Heterosubtypic immunity to influenza A virus infections in mallards may explain existence of multiple virus subtypes.PLoS pathogens · 2013Article
- The NS1 protein of influenza A virus blocks RIG-I-mediated activation of the noncanonical NF-κB pathway and p52/RelB-dependent gene expression in lung epithelial cells.Journal of virology · 2012Article
- Avian influenza rapidly induces antiviral genes in duck lung and intestine.Molecular immunology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Ducks are the natural host and reservoir of influenza viruses. We are interested in their immune responses to these viruses, to understand host-pathogen interactions and to develop effective agricultural vaccines. We identified duck homologues of the chemokines CCL19 and CCL21 and cloned their cognate receptor, CCR7. Conservation of key features, and expression in lymphoid tissues suggests that these chemokines are the direct orthologues of their mammalian counterparts. Mammalian CCL19 and CCL21 are responsible for the homing of dendritic cells and naïve lymphocytes to secondary lymphoid tissues. The contribution of local tertiary lymphoid tissues may be important during influenza infection in ducks. Consistent with leukocyte recruitment, CCL19 and CCL21 transcripts are abundant in lung tissues at 1 day post-infection with highly pathogenic avian influenza A/Vietnam/1203/04 (H5N1) (VN1203). In contrast, expression in lung or intestine tissues infected with low pathogenic A/mallard/BC/500/05 (H5N2) (BC500) is not significant. Recruitment and aggregation of leukocytes is visible in the vicinity of major airways 3 days after infection with VN1203. Chemokine gene expression may serve as a useful marker to evaluate duck immune responses to natural infections and vaccine strains.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.