ArticleThe Journal of allergy and clinical immunology2011
Associations among maternal childhood socioeconomic status, cord blood IgE levels, and repeated wheeze in urban children.
Article in The Journal of allergy and clinical immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00269256 (Stress, Environment, and Genetics in Urban Asthma), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Stress, Environment, and Genetics in Urban Asthma
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Parental Preconception Adversity and Offspring Health in African Americans: A Systematic Review of Intergenerational Studies.Trauma, violence & abuse · 2023Pooled it
- Prenatal maternal stress and wheeze in children: novel insights into epigenetic regulation.Scientific reports · 2016Trial
- Maternal asthma and lung function, childhood asthma and growth: the MAESTRO-Child study.ERJ open research · 2025Article
- An Unfortunate Inheritance: Child Asthma in the Aftermath of Redlining.American journal of respiratory and critical care medicine · 2024Article
- Lower Socioeconomic Status Predicts Increased Proinflammatory Signaling in Late Pregnancy: Evidence From a Filipino Cohort.American journal of human biology : the official journal of the Human Biology Council · 2024Article
- Historical Redlining Impacts Contemporary Environmental and Asthma-related Outcomes in Black Adults.American journal of respiratory and critical care medicine · 2022Article
- Maternal Prenatal Hair Cortisol Is Associated with Child Wheeze among Mothers and Infants with Tobacco Smoke Exposure and Who Face High Socioeconomic Adversity.International journal of environmental research and public health · 2021Article
- Exploring latent classes to identify prenatal and early-life sources of racial disparities in allergic disease.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Article
- Relationship of Cord Blood Immunoglobulin E and Maternal Immunoglobulin E with Birth Order and Maternal History of Allergy in Albanian Mother/Neonate Pairs.Open access Macedonian journal of medical sciences · 2017Article
- Momentary Assessment of Psychosocial Stressors, Context, and Asthma Symptoms in Hispanic Adolescents.Behavior modification · 2016Article
- Time Trends in Racial and Ethnic Disparities in Asthma Prevalence in the United States From the Behavioral Risk Factor Surveillance System (BRFSS) Study (1999-2011).American journal of public health · 2015Article
- Stress and asthma: novel insights on genetic, epigenetic, and immunologic mechanisms.The Journal of allergy and clinical immunology · 2014Review
- Outdoor air pollution and asthma.Lancet (London, England) · 2014Review
- Factors associated with degree of atopy in Latino children in a nationwide pediatric sample: the Genes-environments and Admixture in Latino Asthmatics (GALA II) study.The Journal of allergy and clinical immunology · 2013Article
- The role of early life viral bronchiolitis in the inception of asthma.Current opinion in allergy and clinical immunology · 2013Review
- Psychological stress and hospitalization for childhood asthma-a nationwide cohort study in two Nordic countries.PloS one · 2013Article
- Recent advances in the epidemiologic investigation of risk factors for asthma: a review of the 2011 literature.Current allergy and asthma reports · 2012Review
- Psychosocial stress and asthma morbidity.Current opinion in allergy and clinical immunology · 2012Review
- The association between community stressors and asthma prevalence of school children in Winnipeg, Canada.International journal of environmental research and public health · 2012Article
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5 authors at 3 institutions in 1 country.
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Abstract
backgroundIndependent of current socioeconomic status (SES), past maternal SES might influence asthma outcomes in children.
objectiveWe examined associations among the mother's SES in the first 10 years of her life (maternal childhood SES), increased cord blood IgE levels (upper 20% [1.37 IU/mL]), and repeated wheeze (≥ 2 episodes by age 2 years) in an urban pregnancy cohort (n = 510).
methodsData on sociodemographics, discrimination, financial strain, community violence, interpersonal trauma, and other negative events were obtained prenatally. Prenatal household dust was assayed for cockroach and murine allergens, and traffic-related air pollution was estimated by using spatiotemporal land-use regression. Maternal childhood SES was defined by parental home ownership (birth to 10 years). Maternally reported child wheeze was ascertained at 3-month intervals from birth. Using structural equation models, we examined whether outcomes were dependent on maternal childhood SES directly versus indirect relationships operating through (1) cumulative SES-related adversities, (2) the mother's socioeconomic trajectory (adult SES), and (3) current prenatal environmental exposures.
resultsMothers were largely Hispanic (60%) or black (28%), 37% had not completed high school, and 56% reported parental home ownership. When associations between low maternal childhood SES and repeated wheeze were examined, there were significant indirect effects operating through adult SES and prenatal cumulative stress (β = 0.28, P = .003) and pollution (β = 0.24, P = .004; P value for total indirect effects ≤ .04 for both pathways). Low maternal childhood SES was directly related to increased cord blood IgE levels (β = 0.21, P = .003). Maternal cumulative adversity (interpersonal trauma) was also associated with increased cord blood IgE levels (β = 0.19, P = .01), although this did not explain maternal childhood SES effects.
conclusionLower maternal childhood SES was associated with increased cord blood IgE levels and repeated wheeze through both direct and indirect effects, providing new insights into the role of social inequalities as determinants of childhood respiratory risk.
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