ReviewBiochimica et biophysica acta2012
Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate.
Review in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 89 citations in OpenAlex.
- Caspase Domain Duplication During the Evolution of Caspase-16.Journal of molecular evolution · 2025Article
- Role of Caspase-8 on Retinal Endothelial Cell Migration and Angiogenesis.Annals of vascular medicine and research · 2023Article
- Regulation of distinct caspase-8 functions in retinal ganglion cells and astroglia in experimental glaucoma.Neurobiology of disease · 2021Article
- COVID-19 and Parkinson's Disease: Shared Inflammatory Pathways Under Oxidative Stress.Brain sciences · 2020Article
- The Role of Necroptosis in ROS-Mediated Cancer Therapies and Its Promising Applications.Cancers · 2020Review
- Alternative Pathways of IL-1 Activation, and Its Role in Health and Disease.Frontiers in immunology · 2020Review
- Interleukin-1 as Innate Mediator of T Cell Immunity.Frontiers in immunology · 2020Review
- Caffeic Acid Prevented LPS-Induced Injury of Primary Bovine Mammary Epithelial Cells through Inhibiting NF-Mediators of inflammation · 2019Article
- Gene expression imputation identifies candidate genes and susceptibility loci associated with cutaneous squamous cell carcinoma.Nature communications · 2018Article
- Perturbing mitosis for anti-cancer therapy: is cell death the only answer?EMBO reports · 2018Review
- Neuroprotective Effect of DAHP via Antiapoptosis in Cerebral Ischemia.Behavioural neurology · 2018Article
- Secretory stressors induce intracellular death receptor accumulation to control apoptosis.Cell death & disease · 2017Article
- Caspase-10 Negatively Regulates Caspase-8-Mediated Cell Death, Switching the Response to CD95L in Favor of NF-κB Activation and Cell Survival.Cell reports · 2017Article
- Post-translational modifications as key regulators of TNF-induced necroptosis.Cell death & disease · 2016Review
- Onto better TRAILs for cancer treatment.Cell death and differentiation · 2016Review
- Insertion of an SVA-E retrotransposon into the CASP8 gene is associated with protection against prostate cancer.Human molecular genetics · 2016Article
- Review
- New basal cell carcinoma susceptibility loci.Nature communications · 2015Article
- Advanced research on vasculogenic mimicry in cancer.Journal of cellular and molecular medicine · 2015Review
- Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates.Cell death and differentiation · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Caspase-8, the initiator of extrinsically-triggered apoptosis, also has important functions in cellular activation and differentiation downstream of a variety of cell surface receptors. It has become increasingly clear that the heterodimer of caspase-8 with the long isoform of cellular FLIP (FLIP(L)) fulfills these pro-survival functions of caspase-8. FLIP(L), a catalytically defective caspase-8 paralog, can interact with caspase-8 to activate its catalytic function. The caspase-8/FLIP(L) heterodimer has a restricted substrate repertoire and does not induce apoptosis. In essence, caspase-8 heterodimerized with FLIP(L) prevents the receptor interacting kinases RIPK1 and -3 from executing the form of cell death known as necroptosis. This review discusses the latest insights in caspase-8 homo- versus heterodimerization and the implication this has for cellular death or survival. This article is part of a Special Issue entitled: Proteolysis 50 years after the discovery of lysosome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.