Evidence map›Paper›PMID 21704022›Full record

ReviewBiochemical pharmacology2011

Recent advances in gene manipulation and nicotinic acetylcholine receptor biology.

Anne Tammimäki, William J Horton, Jerry A Stitzel

Abstract readReview
In one paragraph

Review in Biochemical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Cotinine conundrum--a step forward but questions remain.Journal of the National Cancer Institute · 2012
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anne TammimäkiInstitute for Behavioral Genetics, University of Colorado at Boulder, UCB 447, Boulder, CO 80309, United States. anne.tammimaki@colorado.edu
William J Horton
Jerry A Stitzel

Funding

The Collaborative Genetic Study of Nicotine DependenceP01CA089392 · NCI · WASHINGTON UNIVERSITY · PI BIERUT, LAURA J. · 2001 to 2012
$17.3M
Research Training-Genetics of Substance AbuseT32DA017637 · NIDA · UNIVERSITY OF COLORADO AT BOULDER · PI STITZEL, JERRY A · 2004 to 2023
$5.3M
Function of the CHRNA5 D398N SNP: implications for addiction and lung cancer risR21DA026918 · NIDA · UNIVERSITY OF COLORADO · PI STITZEL, JERRY A · 2009 to 2010
$917k
NCI NIH HHS CA089392NCI NIH HHS P01 CA089392NIDA NIH HHS DA017637NIDA NIH HHS DA026918NIDA NIH HHS R21 DA026918NIDA NIH HHS T32 DA017637
6 · The paper itself

Abstract

Pharmacological and immunological methods have been valuable for both identifying some native nicotinic acetylcholine receptor (nAChR) subtypes that exist in vivo and determining the neurobiological and behavioral role of certain nAChR subtypes. However, these approaches suffer from shortage of subtype specific ligands and reliable immunological reagents. Consequently, genetic approaches have been developed to complement earlier approaches to identify native nAChR subtypes and to assess the contribution of nAChRs to brain function and behavior. In this review we describe how assembly partners, knock-in mice and targeted lentiviral re-expression of genes have been utilized to improve our understanding of nAChR neurobiology. In addition, we summarize emerging genetic tools in nAChR research.

Indexed as

Drug DiscoveryGene TargetingAnimalsBrainHumansMiceProtein SubunitsReceptors, NicotinicProtein SubunitsReceptors, Nicotinic

Identifiers

PMID21704022
PMCPMC3162071

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.