ArticleThe American journal of pathology2011
Dual functionality of myeloperoxidase in rotenone-exposed brain-resident immune cells.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- Cocaine use is associated with cerebral white matter hyperintensities in HIV disease.Annals of clinical and translational neurology · 2023Article
- Curcumin modulation of L-dopa and rasagiline-induced neuroprotection in rotenone model of Parkinson's disease.Iranian journal of basic medical sciences · 2023Article
- d-mannose suppresses oxidative response and blocks phagocytosis in experimental neuroinflammation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Glial TIM-3 Modulates Immune Responses in the Brain Tumor Microenvironment.Cancer research · 2020Article
- Ethyl pyruvate does not require microglia for mediating neuroprotection after excitotoxic injury.CNS neuroscience & therapeutics · 2017Article
- Octreotide ameliorates inflammation and apoptosis in acute and kindled murine PTZ paradigms.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- Serotonin as a putative scavenger of hypohalous acid in the brain.Biochimica et biophysica acta · 2016Article
- Effect of pioglitazone on excitotoxic neuronal damage in the mouse hippocampus.Biomolecules & therapeutics · 2015Article
- Inflaming the diseased brain: a role for tainted melanins.Biochimica et biophysica acta · 2015Article
- The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia.Nature communications · 2015Article
- Inflammatory biomarkers, cerebral microbleeds, and small vessel disease: Framingham Heart Study.Neurology · 2015Article
- Resveratrol confers protection against rotenone-induced neurotoxicity by modulating myeloperoxidase levels in glial cells.PloS one · 2013Article
- Myeloperoxidase-derived oxidants induce blood-brain barrier dysfunction in vitro and in vivo.PloS one · 2013Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rotenone exposure has emerged as an environmental risk factor for inflammation-associated neurodegenerative diseases. However, the underlying mechanisms responsible for the harmful effects of rotenone in the brain remain poorly understood. Herein, we report that myeloperoxidase (MPO) may have a potential regulatory role in rotenone-exposed brain-resident immune cells. We show that microglia, unlike neurons, do not undergo death; instead, they exhibit distinctive activated properties under rotenone-exposed conditions. Once activated by rotenone, microglia show increased production of reactive oxygen species, particularly HOCl. Notably, MPO, an HOCl-producing enzyme that is undetectable under normal conditions, is significantly increased after exposure to rotenone. MPO-exposed glial cells also display characteristics of activated cells, producing proinflammatory cytokines and increasing their phagocytic activity. Interestingly, our studies with MPO inhibitors and MPO-knockout mice reveal that MPO deficiency potentiates, rather than inhibits, the rotenone-induced activated state of glia and promotes glial cell death. Furthermore, rotenone-triggered neuronal injury was more apparent in co-cultures with glial cells from Mpo(-/-) mice than in those from wild-type mice. Collectively, our data provide evidence that MPO has dual functionality under rotenone-exposed conditions, playing a critical regulatory role in modulating pathological and protective events in the brain.
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