ArticleClinical immunology (Orlando, Fla.)2011
Assessing immune function by profiling cytokine release from stimulated blood leukocytes and the risk of infection in rheumatoid arthritis.
Article in Clinical immunology (Orlando, Fla.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Serum interleukin-30 level in patients with psoriasis and its correlation with psoriasis severity: a case-control study.The Journal of international medical research · 2021Article
- Predicting Risk of Infection in Patients with Newly Diagnosed Multiple Myeloma: Utility of Immune Profiling.Frontiers in immunology · 2017Article
- PGK1, a glucose metabolism enzyme, may play an important role in rheumatoid arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Article
- M3 mAChR-mediated IL-8 expression through PKC/NF-κB signaling pathways.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2014Article
- Inflammatory cytokines in aqueous humor of patients with choroidal neovascularization.Molecular vision · 2012Article
- Tenocytes, pro-inflammatory cytokines and leukocytes: a relationship?Muscles, ligaments and tendons journal · 2011Article
Corrections and comments
- Erratum issuedStrausbach, Michael A [corrected to Strausbauch, Michael A]
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Persons with rheumatoid arthritis (RA) suffer a high burden of infections, but currently no biomarkers are available to identify individuals at greatest risk. A prospective longitudinal study was therefore conducted to determine the association between the responsiveness of ex vivo cytokine production and 6-month risk of infections. Infections were identified by billing codes and validated by medical record review. At baseline, the release of 17 cytokines by peripheral blood mononuclear cells in response to stimulation, or media alone, was measured using multiplexed cytokine analysis. Production of IL-2, IL-8, IL-10, IL-17, TNF-α, IFN-γ, and GM-CSF, induced by various conditions, was significantly associated with the occurrence of infections. A multivariable prediction model based on these data provided new information on the risk of infection beyond standard assessments of disease activity, severity, and treatment. Future studies could utilize this information to devise new biomarkers for the prediction of infection in patients with RA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.