ArticleGrowth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society2011
Expression of insulin-like growth factor 1 isoforms in the rabbit oculomotor system.
Article in Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 17 citations in OpenAlex.
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- Nystagmus Associated With the Absence of MYOD Expression Across the Lifespan in Extraocular and Limb Muscles.Investigative ophthalmology & visual science · 2023Article
- Review
- Association ofMolecular vision · 2022Article
- Extraocular muscle regeneration in zebrafish requires late signals from Insulin-like growth factors.PloS one · 2018Article
- Extraocular Muscle Repair and Regeneration.Current ophthalmology reports · 2017Article
- Abnormally Small Neuromuscular Junctions in the Extraocular Muscles From Subjects With Idiopathic Nystagmus and Nystagmus Associated With Albinism.Investigative ophthalmology & visual science · 2016Article
- Adaptation of slow myofibers: the effect of sustained BDNF treatment of extraocular muscles in infant nonhuman primates.Investigative ophthalmology & visual science · 2015Article
- Adaptability of the Immature Ocular Motor Control System: Unilateral IGF-1 Medial Rectus Treatment.Investigative ophthalmology & visual science · 2015Article
- Differences in gene expression between strabismic and normal human extraocular muscles.Investigative ophthalmology & visual science · 2012Article
- Effects of sequential injections of hepatocyte growth factor and insulin-like growth factor-I on adult rabbit extraocular muscle.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2012Article
- Analysis of spontaneous and nerve-evoked calcium transients in intact extraocular muscles in vitro.Experimental eye research · 2012Article
- Childhood Onset Strabismus: A Neurotrophic Factor Hypothesis.Journal of binocular vision and ocular motilityArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveThe insulin-like growth factor-1 (IGF-1) gene encodes two isoforms, IGF-1Ea and IGF-1Eb. Both isoforms can regulate skeletal muscle growth and strength. It has been suggested that IGF-Eb may be more potent in promoting skeletal muscle hypertrophy. Precise contractile force regulation is particularly important in the oculomotor system. However, expression of these isoforms in mammalian extraocular muscles (EOMs) is unknown. Here, we examined their expression in rabbit EOMs and the innervating nerve, two potential sources for myogenic growth factors, and compared isoform expression between EOMs and limb skeletal muscles.
designExpression of IGF-1 isoforms was quantified by real-time RT-PCR in adult rabbit EOMs, trochlear and ophthalmic nerves, and compared with expression in rabbit limb skeletal muscles. The presence of mature IGF-1 peptide in the muscles was further examined by Western blot.
resultsBoth IGF-1Ea and IGF-1Eb were expressed in the EOM and the trochlear nerve. Both isoforms were expressed at significantly higher levels (9-fold) in EOM than in limb skeletal muscle. Transcripts of IGF-1 isoforms, of IGF-1 receptor and of IGF binding proteins showed a gradient distribution along the EOM from proximal to distal. The mature IGF-1 protein showed the same gradient distribution in the EOM.
conclusionsExpression of relatively abundant amounts of both IGF-1 splicing isoforms in EOMs, and at a significantly higher level than in limb skeletal muscle, underscores the potential relevance of these myogenic growth factors in EOM plasticity and force regulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.