Evidence map›Paper›PMID 21703584›Full record

ReviewPM & R : the journal of injury, function, and rehabilitation2011

Biological basis of exercise-based treatments: spinal cord injury.

D Michele Basso, Christopher N Hansen

Abstract readReview
In one paragraph

Review in PM & R : the journal of injury, function, and rehabilitation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Elevated MMP-9 in the lumbar cord early after thoracic spinal cord injury impedes motor relearning in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

D Michele BassoCenter for Brain and Spinal Cord Repair, School of Allied Medical Professions, The Ohio State University, 106 Atwell Hall, 453 W 10th Ave, Columbus, OH 43210, USA.
Christopher N Hansen

Funding

Behavioral and Cellular Determinants of Treadmill Training and Recovery After SCIR01NS074882 · NINDS · OHIO STATE UNIVERSITY · PI BASSO, D M · 2011 to 2020
$3.3M
SPARING AND EXERCISE TRAINING PROMOTE RECOVERY IN SCIR01NS043798 · NINDS · OHIO STATE UNIVERSITY · PI BASSO, D. MICHELE · 2002 to 2006
$1.4M
NINDS NIH HHS NS043798NINDS NIH HHS R01 NS043798NINDS NIH HHS R01 NS074882
6 · The paper itself

Abstract

Despite intensive neurorehabilitation, extensive functional recovery after spinal cord injury is unattainable for most individuals. Optimal recovery will likely depend on activity-based, task-specific training that personalizes the timing of intervention with the severity of injury. Exercise paradigms elicit both beneficial and deleterious biophysical effects after spinal cord injury. Modulating the type, intensity, complexity, and timing of training may minimize risk and induce greater recovery. This review discusses the following: (a) the biological underpinning of training paradigms that promote motor relearning and recovery, and (b) how exercise interacts with cellular cascades after spinal cord injury. Clinical implications are discussed throughout.

Indexed as

Recovery of FunctionSpinal Cord InjuriesAnimalsBiomarkersExercise TherapyHumansNeuronal PlasticityBiomarkers

Identifiers

PMID21703584
PMCPMC5021444

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.