ArticleImmunity2011
Mast cells are key promoters of contact allergy that mediate the adjuvant effects of haptens.
Article in Immunity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 232 papers.
What it found
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Who cites it
232 citing papers in PubMed, 448 citations in OpenAlex.
- Mast Cells in Host Defense Against Cutaneous Staphylococcus aureus Infection.Immunology and cell biology · 2026Review
- Context-dependent regulation of mast cell-mediated food allergy in C57BL/6J mice.The Journal of allergy and clinical immunology · 2026Article
- Mast Cells in the Developing Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Review
- Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches.Pharmacological reviews · 2026Review
- Examining the immunomodulatory role of nanoparticles on mast cell activation.Scientific reports · 2026Article
- Live imaging of skin immunity using two-photon microscopy: a short review.Inflammation and regeneration · 2026Review
- Platelet-mediated activation of perivascular mast cells triggers progression of sepsis to septic shock in mice.Nature communications · 2025Article
- Insights Into Complex Murine Models of Allergy and Anaphylaxis: The Central Role of IgE and Mast Cells in Advancing Human Therapies.European journal of immunology · 2025Review
- TRPV1 Blocker, Peptide HCRG21 from Sea AnemoneInternational journal of molecular sciences · 2025Article
- Article
- Sustained learned immunosuppression could not prevent local allergic ear swelling in a rat model of contact hypersensitivity.Scientific reports · 2025Article
- Guilty by association: direct interaction with the tetraspanin CD63 suggests a role for organic cation transporter 3 in histamine release from granulocytes.Journal of biomedical science · 2025Article
- Cutaneous T cell immunity.Nature immunology · 2025Review
- The crosstalk of monocyte-neutrophil in hair follicles regulates neutrophil transepidermal migration in contact dermatitis.Communications biology · 2025Article
- Bullous Pemphigoid and Epidemiological Patterns in Northern Greece: Insights from an 8-Year Observational Study.Dermatology practical & conceptual · 2025Article
- Neurogenic Inflammation in Allergic Contact Dermatitis.Biomedicines · 2025Review
- Transcriptional regulation of basophil-specific protease genes by C/EBPα, GATA2, TGF-β signaling, and epigenetic mechanisms.FEBS letters · 2025Article
- Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation.Science (New York, N.Y.) · 2025Article
- Cromolyn sodium reduces LPS-induced pulmonary fibrosis by inhibiting the EMT process enhanced by MC-derived IL-13.Respiratory research · 2025Article
- Wenqing Yin Attenuates the Allergic Contact Dermatitis Response by Inhibiting the JAK2/STAT1 and MAPK Signaling Pathways.Journal of inflammation research · 2025Article
172 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A prominent feature of sensitizing environmental compounds that cause allergic contact dermatitis is the rapid induction of an innate inflammatory response that seems to provide danger signals for efficient T cell priming. We generated mouse models of mast cell deficiency, mast cell-specific gene inactivation, and mast cell reporter mice for intravital imaging and showed that these adjuvant effects of contact allergens are mediated by mast cells and histamine. Mast cell deficiency resulted in impaired emigration of skin DCs to the lymph node and contact hypersensitivity was dramatically reduced in the absence of mast cells. In addition, mast cell-specific inactivation of the Il10 gene did not reveal any role for mast cell-derived IL-10 in the regulation of contact allergy. Collectively, we demonstrate that mast cells are essential promoters of contact hypersensitivity, thereby highlighting their potential to promote immune responses to antigens entering via the skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.