ArticleJournal of the American Academy of Child and Adolescent Psychiatry2011
Normalization of cortical gray matter deficits in nonpsychotic siblings of patients with childhood-onset schizophrenia.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Longitudinal Structural MRI Findings in Individuals at Genetic and Clinical High Risk for Psychosis: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- A familial risk enriched cohort as a platform for testing early interventions to prevent severe mental illness.BMC psychiatry · 2014Trial
- Schizophrenia: from mechanism to therapy.Science China. Life sciences · 2026Review
- Accelerated brain aging associated with executive deficits in adolescence and early adulthood among individuals with schizophrenia and genetic high risk.BMC psychiatry · 2026Article
- Investigating amplitude of low-frequency fluctuation and possible links with cognitive impairment in childhood and adolescence onset schizophrenia: a correlation study.Frontiers in psychiatry · 2024Article
- Neurodevelopmental trajectories, polygenic risk, and lipometabolism in vulnerability and resilience to schizophrenia.BMC psychiatry · 2023Article
- Clustering of cognitive subtypes in schizophrenia patients and their siblings: relationship with regional brain volumes.Schizophrenia (Heidelberg, Germany) · 2022Article
- Age-associated network controllability changes in first episode drug-naïve schizophrenia.BMC psychiatry · 2022Article
- Abnormal Brain Structure Morphology in Early-Onset Schizophrenia.Frontiers in psychiatry · 2022Article
- Altered resting-state functional connectivity in young children at familial high risk for psychotic illness: A preliminary study.Schizophrenia research · 2020Article
- Genetics of Childhood-onset Schizophrenia 2019 Update.Child and adolescent psychiatric clinics of North America · 2020Review
- Amplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study.Archives of medical science : AMS · 2019Article
- Childhood-Onset Schizophrenia: Insights from Induced Pluripotent Stem Cells.International journal of molecular sciences · 2018Review
- Association of Prenatal Exposure to Population-Wide Folic Acid Fortification With Altered Cerebral Cortex Maturation in Youths.JAMA psychiatry · 2018Observational
- Interactome analysis reveals ZNF804A, a schizophrenia risk gene, as a novel component of protein translational machinery critical for embryonic neurodevelopment.Molecular psychiatry · 2018Article
- A prenatal interruption of DISC1 function in the brain exhibits a lasting impact on adult behaviors, brain metabolism, and interneuron development.Oncotarget · 2017Article
- Neuroimaging findings from childhood onset schizophrenia patients and their non-psychotic siblings.Schizophrenia research · 2016Review
- Severity of Cortical Thinning Correlates With Schizophrenia Spectrum Symptoms.Journal of the American Academy of Child and Adolescent Psychiatry · 2016Article
- Early Cannabis Use, Polygenic Risk Score for Schizophrenia and Brain Maturation in Adolescence.JAMA psychiatry · 2015Observational
- Dysplasticity, metaplasticity, and schizophrenia: Implications for risk, illness, and novel interventions.Development and psychopathology · 2015Review
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Authors and funding
9 authors.
Funding
Abstract
objectiveCortical gray matter (GM) abnormalities in patients with childhood-onset schizophrenia (COS) progress during adolescence ultimately localizing to prefrontal and temporal cortices by early adult age. A previous study of 52 nonpsychotic siblings of COS probands had significant prefrontal and temporal GM deficits that appeared to "normalize" by age 17 years. Here we present a replication with nonoverlapping groups of healthy full siblings and healthy controls.
methodUsing an automated measure and prospectively acquired anatomical brain magnetic resonance images, we mapped cortical GM thickness in nonpsychotic full siblings (n = 43, 68 scans; ages 5 through 26 years) of patients with COS, contrasting them with age-, gender-, and scan interval-matched healthy controls (n = 86, 136 scans). The false-discovery rate procedure was used to control for type I errors due to multiple comparisons.
resultsAs in our previous study, young nonpsychotic siblings (<17 years) showed significant GM deficits in bilateral prefrontal and left temporal cortices and, in addition, smaller deficits in the parietal and right inferior temporal cortices. These deficits in nonpsychotic siblings normalized with age with minimal abnormalities remaining by age 17.
conclusionsOur results support previous findings showing nonpsychotic siblings of COS probands to have early GM deficits that ameliorate with time. At early ages, prefrontal and/or temporal loss may serve as a familial/trait marker for COS. Late adolescence appears to be a critical period for greatest localization of deficits in probands or normalization in nonpsychotic siblings.
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