ArticleJournal of the American Academy of Child and Adolescent Psychiatry2011
Identification of genetic loci underlying the phenotypic constructs of autism spectrum disorders.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study.Autism research : official journal of the International Society for Autism Research · 2022Article
- Drug development for Autism Spectrum Disorder (ASD): Progress, challenges, and future directions.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2021Review
- Using the big data approach to clarify the structure of restricted and repetitive behaviors across the most commonly used autism spectrum disorder measures.Molecular autism · 2021Article
- Quantitative genome-wide association study of six phenotypic subdomains identifies novel genome-wide significant variants in autism spectrum disorder.Translational psychiatry · 2020Article
- Structural hierarchy of autism spectrum disorder symptoms: an integrative framework.Journal of child psychology and psychiatry, and allied disciplines · 2018Article
- Article
- A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity?Biological psychiatry · 2015Article
- Genome-Wide Association Study for Autism Spectrum Disorder in Taiwanese Han Population.PloS one · 2015Article
- Behavioral signatures related to genetic disorders in autism.Molecular autism · 2014Article
- Genetic influences on receptive joint attention in chimpanzees (Pan troglodytes).Scientific reports · 2014Article
- A molecular genetic study of autism and related phenotypes in extended pedigrees.Journal of neurodevelopmental disorders · 2013Article
- Individual common variants exert weak effects on the risk for autism spectrum disorders.Human molecular genetics · 2012Article
- Examining autism spectrum disorders by biomarkers: example from the oxytocin and serotonin systems.Journal of the American Academy of Child and Adolescent Psychiatry · 2012Article
- A multivariate twin study of autistic traits in 12-year-olds: testing the fractionable autism triad hypothesis.Behavior genetics · 2012Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveTo investigate the underlying phenotypic constructs in autism spectrum disorders (ASD) and to identify genetic loci that are linked to these empirically derived factors.
methodExploratory factor analysis was applied to two datasets with 28 selected Autism Diagnostic Interview-Revised (ADI-R) algorithm items. The first dataset was from the Autism Genome Project (AGP) phase I (1,236 ASD subjects from 618 families); the second was from the AGP phase II (804 unrelated ASD subjects). Variables derived from the factor analysis were then used as quantitative traits in genome-wide variance components linkage analyses.
resultsSix factors, namely, joint attention, social interaction and communication, nonverbal communication, repetitive sensory-motor behavior, peer interaction, and compulsion/restricted interests, were retained for both datasets. There was good agreement between the factor loading patterns from the two datasets. All factors showed familial aggregation. Suggestive evidence for linkage was obtained for the joint attention factor on 11q23. Genome-wide significant evidence for linkage was obtained for the repetitive sensory-motor behavior factor on 19q13.3.
conclusionsThis study demonstrates that the underlying phenotypic constructs based on the ADI-R algorithm items are replicable in independent datasets, and that the empirically derived factors are suitable and informative in genetic studies of ASD.
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