ArticleThe American journal of pathology2011
Compartment-specific remodeling of splenic micro-architecture during experimental visceral leishmaniasis.
Article in The American journal of pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 47 citations in OpenAlex.
- Transcriptional signatures in human macrophage-like cells infected by Leishmania infantum, Leishmania major and Leishmania tropica.PLoS neglected tropical diseases · 2024Article
- Inflammatory CD11bPathogens (Basel, Switzerland) · 2024Article
- Article
- Dissecting pathways to thrombocytopenia in a mouse model of visceral leishmaniasis.Blood advances · 2021Article
- Splenic Transcriptional Responses in Severe Visceral Leishmaniasis: Impaired Leukocyte Chemotaxis and Cell Cycle Arrest.Frontiers in immunology · 2021Article
- Interferon-γ-Producing CD4Frontiers in immunology · 2021Article
- Intravacuolar Pathogens Hijack Host Extracellular Vesicle Biogenesis to Secrete Virulence Factors.Frontiers in immunology · 2021Review
- Article
- Cytokines and splenic remodelling duringCytokine: X · 2020Article
- IL-27 signalling regulates glycolysis in Th1 cells to limit immunopathology during infection.PLoS pathogens · 2020Article
- IL-33/ST2 axis is involved in disease progression in the spleen during Leishmania donovani infection.Parasites & vectors · 2020Article
- Phenotypical Characterization of Spleen Remodeling in Murine Experimental Visceral Leishmaniasis.Frontiers in immunology · 2020Article
- Article
- Tissue-specific transcriptomic changes associated with AmBisome® treatment of BALB/c mice with experimental visceral leishmaniasis.Wellcome open research · 2019Article
- HIF-1α is a key regulator in potentiating suppressor activity and limiting the microbicidal capacity of MDSC-like cells during visceral leishmaniasis.PLoS pathogens · 2017Article
- Interleukin-27 (IL-27) Mediates Susceptibility to Visceral Leishmaniasis by Suppressing the IL-17-Neutrophil Response.Infection and immunity · 2016Article
- Regulation of immunity during visceral Leishmania infection.Parasites & vectors · 2016Review
- Critical role of the C5a-activated neutrophils in high-fat diet-induced vascular inflammation.Scientific reports · 2016Article
- The Contribution of Immune Evasive Mechanisms to Parasite Persistence in Visceral Leishmaniasis.Frontiers in immunology · 2016Review
- Genetic recapitulation of human pre-eclampsia risk during convergent evolution of reduced placental invasiveness in eutherian mammals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Progressive splenomegaly is a hallmark of visceral leishmaniasis in humans, canids, and rodents. In experimental murine visceral leishmaniasis, splenomegaly is accompanied by pronounced changes in microarchitecture, including expansion of the red pulp vascular system, neovascularization of the white pulp, and remodeling of the stromal cell populations that define the B-cell and T-cell compartments. Here, we show that Ly6C/G(+) (Gr-1(+)) cells, including neutrophils and inflammatory monocytes, accumulate in the splenic red pulp during infection. Cell depletion using monoclonal antibody against either Ly6C/G(+) (Gr-1; RB6) or Ly6G(+) (1A8) cells increased parasite burden. In contrast, depletion of Ly6C/G(+) cells, but not Ly6G(+) cells, halted the progressive remodeling of Meca-32(+) and CD31(+) red pulp vasculature. Strikingly, neither treatment affected white pulp neovascularization or the remodeling of the fibroblastic reticular cell and follicular dendritic cell networks. These findings demonstrate a previously unrecognized compartment-dependent selectivity to the process of splenic vascular remodeling during experimental murine visceral leishmaniasis, attributable to Ly6C(+) inflammatory monocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.