Evidence map›Paper›PMID 21703001›Full record

Trial reportBMC complementary and alternative medicine2011

Patient education integrated with acupuncture for relief of cancer-related fatigue randomized controlled feasibility study.

Michael F Johnston, Ron D Hays, Saskia K Subramanian, Robert M Elashoff, Eleanor K Axe, Jie-Jia Li, Irene Kim, Roberto B Vargas, Jihey Lee, LuGe Yang and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC complementary and alternative medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00646633 (Improving Fatigue), which is not on this map. Cited by 40 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 15 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00646633 nacompletednot on this map

Improving Fatigue: A Pilot Study of Acupuncture and Patient Education for Breast Cancer Survivors

TypeinterventionalSponsorJonsson Comprehensive Cancer CenterRan2008 to 2009Enrolled12ConditionsFatigueArmsAcupuncture and patient education
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 15 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Psychostimulants for cancer-related cognitive impairment in adult cancer survivors: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
  4. Pooled it
  5. Effects of acupuncture on cancer-related fatigue: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
    Pooled it
  6. Pooled it
  7. Guideline
  8. Pooled it
  9. Pooled it
  10. Guideline
  11. Guideline
  12. Acupuncture for cancer-related fatigue: a systematic review of randomized clinical trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2013
    Pooled it
  13. Systematic review of acupuncture in cancer care: a synthesis of the evidence.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013
    Pooled it
  14. Pooled it
  15. Pooled it
  16. Trial
  17. Trial
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  19. Trial
  20. Acupuncture for cancer-related fatigue in lung cancer patients: a randomized, double blind, placebo-controlled pilot trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2017
    Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Michael F JohnstonUCLA Center for East-West Medicine, David Geffen School of Medicine at UCLA, LA, USA.
Ron D Hays
Saskia K Subramanian
Robert M Elashoff
Eleanor K Axe
Jie-Jia Li
Irene Kim
Roberto B Vargas
Jihey Lee
LuGe Yang
Ka-Kit Hui
RAND Corporation · USApplied Biomathematics (United States) · USNeurobehavioral Systems · US

Funding

The Center for Health Improvement of Minority ElderlyP30AG021684 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Homero Erwin del Pino · 2002 to 2026
$19.7M
TRAINING COREP20MD000182 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI MILBURN, NORWEETA GERMAINE, SHAPIRO, MARTIN F. · 2002 to 2016
$16.5M
UCLA OLDER AMERICANS INDEPENDENCE CENTERP30AG028748 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOORE, ALISON AHERN · 2006 to 2017
$9.8M
NIA NIH HHS P30AG021684NIA NIH HHS P30 AG028748NIA NIH HHS P30-AG028748NIMHD NIH HHS 2P20MD000182
6 · The paper itself

Abstract

backgroundCancer-related fatigue (CRF) is a prominent clinical problem. There are calls for multi-modal interventions.

methodsWe assessed the feasibility of delivering patient education integrated with acupuncture for relief of CRF in a pilot randomized controlled trial (RCT) with breast cancer survivors using usual care as control. Social cognitive and integrative medicine theories guided integration of patient education with acupuncture into a coherent treatment protocol. The intervention consisted of two parts. First, patients were taught to improve self-care by optimizing exercise routines, improving nutrition, implementing some additional evidence-based cognitive behavioral techniques such as stress management in four weekly 50-minute sessions. Second, patients received eight weekly 50-minute acupuncture sessions. The pre-specified primary outcome, CRF, was assessed with the Brief Fatigue Inventory (BFI). Secondary outcomes included three dimensions of cognitive impairment assessed with the FACT-COGv2.

resultsDue to difficulties in recruitment, we tried several methods that led to the development of a tailored recruitment strategy: we enlisted oncologists into the core research team and recruited patients completing treatment from oncology waiting rooms. Compared to usual care control, the intervention was associated with a 2.38-point decline in fatigue as measured by the BFI (90% Confidence Interval from 0.586 to 5.014; p <0.10). Outcomes associated with cognitive dysfunction were not statistically significant.

conclusionsPatient education integrated with acupuncture had a very promising effect that warrants conducting a larger RCT to confirm findings. An effective recruitment strategy will be essential for the successful execution of a larger-scale trial.

trial registrationNCT00646633.

Indexed as

Acupuncture TherapyHealth BehaviorPatient Education as TopicSelf CareBreast NeoplasmsCognition DisordersDietEvaluation Studies as TopicExerciseFatigueFeasibility StudiesFemaleHumansIntegrative MedicineMiddle AgedRelaxation Therapy

Identifiers

PMID21703001
PMCPMC3144009
OpenAlexW2127936839

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.