ArticleReproductive biology and endocrinology : RB&E2011
In utero protein restriction causes growth delay and alters sperm parameters in adult male rats.
Article in Reproductive biology and endocrinology : RB&E, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 65 citations in OpenAlex.
- Postnatal development outcomes in mice after gestational exposure to polystyrene nanoplastics.Scientific reports · 2026Article
- Maternal protein restriction affects the differentiation of cells in the epididymal epithelium lining of 44-day-old rats.Biology open · 2025Article
- Histomorphometric and oxidative evaluation of the offspring's testis from type 2 diabetic female rats treated with metformin and pentoxifylline.International journal of experimental pathology · 2022Review
- Intrauterine Hyponutrition Reduces Fetal Testosterone Production and Postnatal Sperm Count in the Mouse.Journal of the Endocrine Society · 2022Article
- Maternal Protein Restriction Alters the Expression of Proteins Related to the Structure and Functioning of the Rat Offspring Epididymis in an Age-Dependent Manner.Frontiers in cell and developmental biology · 2022Article
- Fetal Programming Effects of a Mild Food Restriction During Pregnancy in Mice: How Does It Compare to Intragestational Ghrelin Administration?Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Nutrition and its role in epigenetic inheritance of obesity and diabetes across generations.Mammalian genome : official journal of the International Mammalian Genome Society · 2020Review
- Gestational and lactational exposure to gossypol alters the testis transcriptome.BMC genomics · 2020Article
- Maternal energy insufficiency affects testicular development of the offspring in a swine model.Scientific reports · 2019Article
- Article
- Maternal protein restriction differentially alters the expression of AQP1, AQP9 and VEGFr-2 in the epididymis of rat offspring.International journal of molecular sciences · 2019Article
- Impact of uteroplacental insufficiency on postnatal rat male gonad.The Journal of endocrinology · 2017Article
- Current Concepts of Maternal Nutrition.Obstetrical & gynecological survey · 2016Review
- Effects of Parental Dietary Exposure to GM Rice TT51 on the Male Reproductive System of Rat Offspring.Biomedical and environmental sciences : BES · 2016Article
- Effects of 90-Day Feeding of Transgenic Maize BT799 on the Reproductive System in Male Wistar Rats.International journal of environmental research and public health · 2015Article
- Rats undernourished in utero have altered Ca2+ signaling and reduced fertility in adulthood.Physiological reports · 2015Article
- Accelerated aging of reproductive capacity in male rat offspring of protein-restricted mothers is associated with increased testicular and sperm oxidative stress.Age (Dordrecht, Netherlands) · 2014Article
- Article
- Prenatal testosterone exposure worsen the reproductive performance of male rat at adulthood.PloS one · 2013Article
- Short- and long-term reproductive effects of prenatal and lactational growth restriction caused by maternal diabetes in male rats.Reproductive biology and endocrinology : RB&E · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have supported the concept of "fetal programming" which suggests that during the intrauterine development the fetus may be programmed to develop diseases in adulthood. The possible effects of in utero protein restriction on sexual development of rat male offspring were evaluated in the present study.
methodsPregnant Wistar rats were divided into two experimental groups: one group treated with standard chow (SC, n = 8, 17% protein) and the other group treated with hypoproteic chow (HC, n = 10, 6% protein) throughout gestation. After gestation the two experimental groups received standard chow. To evaluate the possible late reproductive effects of in utero protein restriction, the male offspring of both groups were assessed at different phases of sexual development: prepubertal (30 days old); peripubertal (60 days old); adult (90 days old). Student's t-test and Mann-Whitney test were utilized. Differences were considered significant when p < 0.05.
resultsWe found that in utero protein restriction reduced the body weight of male pups on the first postnatal day and during the different sexual development phases (prepubertal, peripubertal and adult). During adulthood, Sertoli cell number, sperm motility and sperm counts in the testis and epididymal cauda were also reduced in HC. Furthermore, the numbers of sperm presenting morphological abnormalities and cytoplasmic drop retention were higher in HC.
conclusionsIn conclusion, in utero protein restriction, under these experimental conditions, causes growth delay and alters male reproductive-system programming in rats, suggesting impairment of sperm quality in adulthood.
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