Evidence map›Paper›PMID 21702654›Full record

ArticleExpert review of respiratory medicine2011

Bacteria and asthma: more there than we thought.

Daniel E Dulek, R Stokes Peebles

Abstract readComment
In one paragraph

Article in Expert review of respiratory medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Re-defining the unique roles for eosinophils in allergic respiratory inflammation.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Daniel E DulekDepartment of Pediatrics, Division of Pediatric Infectious Diseases, Monroe Carell Jr, Children's Hospital at Vanderbilt, Vanderbilt University Medical Center, Nashville, TN, USA.
R Stokes Peebles

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
Viral and Host Determinants of Infant and Childhood Allergy and AsthmaU19AI095227 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Christian Rosas-Salazar · 2011 to 2026
$34.9M
THE PHARMACOLOGY OF INHIBITORS OF HEME PROTEIN-CATALYZED LIPID PEROXIDATIONP50GM015431 · NIGMS · VANDERBILT UNIVERSITY · PI CAPRIOLI, RICHARD M · 1985 to 2010
$15.0M
Therapeutic Modulation of Endothelial Cell TetrahydrobiopterinP01GM015431 · NIGMS · VANDERBILT UNIVERSITY · PI ROBERTS, II, L JACKSON · 2011 to 2015
$9.5M
The Role of PGI2 in Allergic InflammationR01HL090664 · NHLBI · VANDERBILT UNIVERSITY · PI PEEBLES, RAY STOKES · 2009 to 2013
$1.9M
The Role of IL-17 in RSV-induced Mucus and Airway ResponsivenessR01AI070672 · NIAID · VANDERBILT UNIVERSITY · PI PEEBLES, RAY STOKES · 2007 to 2011
$1.9M
The Structure and Function of the CRTH2 PDG2 ReceptorR01AI059108 · NIAID · VANDERBILT UNIVERSITY · PI BREYER, RICHARD M. · 2005 to 2009
$1.8M
The Role of Il-13 in Regulating Th17 Cytokine ProductionR21HL106446 · NHLBI · VANDERBILT UNIVERSITY · PI PEEBLES, RAY STOKES · 2011 to 2012
$439k
The role of cyclooxygenase in the adaptive immune response and toleranceI01BX000624 · VA · VETERANS HEALTH ADMINISTRATION · PI PEEBLES, RAY STOKES · 2009 to 2019
–
BLRD VA I01 BX000624NCRR NIH HHS UL1 RR024975NHLBI NIH HHS R01 HL 090664NHLBI NIH HHS R01 HL090664NHLBI NIH HHS R21 HL106446NIAID NIH HHS R01 AI059108NIAID NIH HHS R01 AI 070672NIAID NIH HHS R01 AI070672NIAID NIH HHS U19 AI095227NIGMS NIH HHS GM015431NIGMS NIH HHS P01 GM015431NIGMS NIH HHS P50 GM015431
6 · The paper itself

Abstract

In a recently performed case-control study, characteristics of the airway microbiota in suboptimally controlled adult asthmatics were compared with those of healthy, nonasthmatic adult subjects. Bacterial burden was significantly greater in asthmatic subjects. Further, increased airway microbiota variability and diversity were correlated with increased bronchial hyper-responsiveness. Although several limitations are present, this study provides an intriguing initial insight into the possible relationship between the airway microbiota and asthma pathogenesis.

Identifiers

PMID21702654
PMCPMC3929126

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.