ArticleAnalytical chemistry2011
DNA sensing by amplifying the number of near-infrared emitting, oligonucleotide-encapsulated silver clusters.
Article in Analytical chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Fluorescence Screening of DNA-AgNCs with Pulsed White Light Excitation.Nano letters · 2024Article
- Optical, structural and antibacterial properties of silver nanoparticles and DNA-templated silver nanoclusters.Nanomedicine (London, England) · 2023Review
- Structure and luminescence of DNA-templated silver clusters.Nanoscale advances · 2021Review
- The spatial organization of trace silver atoms on a DNA template.RSC advances · 2020Review
- Footprints of Nanoscale DNA-Silver Cluster ChromophoresACS nano · 2019Article
- Article
- A Turn-On Detection of DNA Sequences by Means of Fluorescence of DNA-Templated Silver Nanoclusters via Unique Interactions of a Hydrated Ionic Liquid.Molecules (Basel, Switzerland) · 2018Article
- A Biofunctional Molecular Beacon for Detecting Single Base Mutations in Cancer Cells.Molecular therapy. Nucleic acids · 2016Article
- A Segregated, Partially Oxidized, and Compact Ag10 Cluster within an Encapsulating DNA Host.Journal of the American Chemical Society · 2016Article
- DNA-Directed Fluorescence Switching of Silver Clusters.The journal of physical chemistry. C, Nanomaterials and interfaces · 2015Article
- A complementary palette of NanoCluster Beacons.ACS nano · 2014Article
- Near-infrared silver cluster optically signaling oligonucleotide hybridization and assembling two DNA hosts.Analytical chemistry · 2014Article
- Magic Numbers in DNA-Stabilized Fluorescent Silver Clusters Lead to Magic Colors.The journal of physical chemistry letters · 2014Article
- A silver cluster-DNA equilibrium.Analytical chemistry · 2013Article
- DNA/RNA Detection Using DNA-Templated Few-Atom Silver Nanoclusters.Biosensors · 2013Review
- Silver clusters as both chromophoric reporters and DNA ligands.Analytical chemistry · 2013Article
- A fluorescence light-up Ag nanocluster probe that discriminates single-nucleotide variants by emission color.Journal of the American Chemical Society · 2012Article
- Optical sensing by transforming chromophoric silver clusters in DNA nanoreactors.Analytical chemistry · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
A bifunctional oligonucleotide integrates in situ synthesis of a fluorogenic silver cluster with recognition of a target DNA sequence. With the template C(3)AC(3)AC(3)GC(3)A, a complex forms with 10 silver atoms that possesses electronic transitions in the near-infrared and that is detected at nanomolar concentrations using diode laser excitation. Pendant to this cluster encoding region, the recognition component binds a target DNA strand through hybridization, and decoupling of these two regions of the composite sensor renders a modular sensor for specific oligonucleotides. A target is detected using a quencher strand that bridges the cluster template and recognition components and disturbs cluster binding, as indicated by static quenching. Competitive displacement of the quencher by the target strand restores the favored cluster environment, and our key finding is that this exchange enhances emission through a proportional increase in the number of emissive clusters. DNA detection is also accomplished in serum-containing buffers by taking advantage of the high brightness of this fluorophore and the inherently low endogenous background in the near-infrared spectral region. Cluster stability in this biological environment is enhanced by supplementing the solutions with Ag(+).
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