ArticleDiabetologia2011
Insulitis in the human endocrine pancreas: does a viral infection lead to inflammation and beta cell replication?
Article in Diabetologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Properties of Two Enterovirus Antibodies that are Utilized in Diabetes Research.Scientific reports · 2016Article
- Enterovirus and type 1 diabetes: What is the matter?World journal of diabetes · 2015Review
- Insulitis in human type 1 diabetes: a comparison between patients and animal models.Seminars in immunopathology · 2014Review
- Biliary tree stem cells, precursors to pancreatic committed progenitors: evidence for possible life-long pancreatic organogenesis.Stem cells (Dayton, Ohio) · 2013Article
- Phenylmethimazole suppresses dsRNA-induced cytotoxicity and inflammatory cytokines in murine pancreatic beta cells and blocks viral acceleration of type 1 diabetes in NOD mice.Molecules (Basel, Switzerland) · 2013Article
- Prevention or acceleration of type 1 diabetes by viruses.Cellular and molecular life sciences : CMLS · 2013Review
- Destruction of tissue, cells and organelles in type 1 diabetic rats presented at macromolecular resolution.Scientific reports · 2013Article
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1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Defining the role of viruses in the aetiopathogenesis of human type 1 diabetes has been an elusive goal for more than 40 years, although indirect evidence is mounting that viruses have an important modulatory role in the development of the disease through their interaction with the innate immune system. In this issue of Diabetologia, Willcox et al. provide histopathological evidence that the islets of Langerhans in seven young patients with recent-onset disease expressed the enteroviral protein VP1 and report that this marker is preferentially present in islets that show signs of enhanced replicative activity. They suggest that insulitis may be the common factor linking beta cell replication and VP1 positivity, with persistent virus infection leading to chemokine secretion, infiltration of immune cells (insulitis) and pro-inflammatory cytokine-induced beta cell replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.