ArticleJournal of laboratory physicians2011
Inducible Clindamycin Resistance in Staphylococcus aureus Isolated from Clinical Samples.
Article in Journal of laboratory physicians, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- Epidemiology of Infections Caused by Gram-Positive Cocci-Microorganisms · 2026Review
- Phenotypic and Genotypic Characteristics ofToxins · 2026Article
- Clindamycin and daptomycin failure in PVL-positive MRSA infection of the skin and soft tissue.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2026Article
- Perinatal Occurrence and Epidemiological Significance ofAnimals : an open access journal from MDPI · 2026Article
- Detection and Genotypic Characterization of Clindamycin Resistance AmongScientifica · 2026Article
- Article
- Clindamycin-resistant among Staphylococcus aureus: Investigation into phenotypic and genotypic profiles.PloS one · 2025Article
- Inducible clindamycin-resistant and biofilm formation in the Staphylococcus aureus isolated from healthcare worker's anterior nasal carriage.BMC research notes · 2024Article
- Antimicrobial Resistance Patterns of Outpatient Staphylococcus aureus Isolates.JAMA network open · 2024Article
- Staphylococcal skin infection isolates from dogs without recent antibiotic exposure are 100% susceptible to clindamycin.Frontiers in veterinary science · 2024Article
- Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance ofmSystems · 2023Article
- Metal nanoparticles as inhibitors of enzymes and toxins of multidrug-resistantInfectious medicine · 2023Review
- The Silent Threat: Antimicrobial-Resistant Pathogens in Food-Producing Animals and Their Impact on Public Health.Microorganisms · 2023Review
- A Multicenter Experience of Inducible Clindamycin Resistance in Staphylococcus aureus Infection among 800 Egyptian Patients with or without Diabetes Mellitus.The American journal of tropical medicine and hygiene · 2023Article
- Nasal Carriage of Methicillin-ResistantThe East African health research journal · 2023Article
- Phenotypic detection of methicillin resistance, biofilm production, and inducible clindamycin resistance in Staphylococcus aureus clinical isolates in Kathmandu, Nepal.Tropical medicine and health · 2022Article
- Antimicrobial Susceptibility Profiles and Molecular Characterisation ofAntibiotics (Basel, Switzerland) · 2022Article
- Inducible Clindamycin Resistant Staphylococcus aureus among Patients Attending Tertiary Care Centre: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2021Article
- Article
- Association of β-Lactam Allergy Documentation and Prophylactic Antibiotic Use in Surgery: A National Cross-Sectional Study of Hospitalized Patients.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionThe resistance to antimicrobial agents among Staphylococci is an increasing problem. This has led to renewed interest in the usage of Macrolide-Lincosamide-Streptogramin B (MLS(B)) antibiotics to treat Staphylococcus aureus (S. aureus) infections. The resistance to macrolide can be mediated by msr A gene coding for efflux mechanism or via erm gene encoding for enzymes that confer inducible or constitutive resistance to MLS(B)antibiotics. In vitro routine tests for clindamycin susceptibility may fail to detect inducible clindamycin resistance due to erm genes resulting in treatment failure, thus necessitating the need to detect such resistance by a simple D test on a routine basis. MATERIALS AND
methodsOne hundred and ninety S. aureus isolates were subjected to routine antibiotic susceptibility testing including oxacillin (1 µg) and cefoxitin (30 µg) by modified Kirby Bauer disc diffusion method. Inducible resistance to clindamycin in S. aureus was tested by 'D test' as per CLSI guidelines.
resultsTwenty (10%) isolates showed inducible clindamycin resistance, 18 (9%) showed constitutive resistance while remaining 16 (8%) showed MS phenotype. Inducible resistance and constitutive resistance were found to be higher in MRSA as compared to MSSA (20%, 16% and 6%, 6%, respectively).
conclusionClindamycin is kept as a reserve drug and is usually advocated in severe MRSA infections depending upon the antimicrobial susceptibility results. This study showed that D test should be used as a mandatory method in routine disc diffusion testing to detect inducible clindamycin resistance in Staphylococci for the optimum treatment of patients.
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