ArticlePloS one2011
Detection of human bocavirus mRNA in respiratory secretions correlates with high viral load and concurrent diarrhea.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- High rates of detection of respiratory viruses in tonsillar tissues from children with chronic adenotonsillar disease.PloS one · 2012Trial
- Twenty years of human bocavirus research: from an unculturable virus of unclear pathogenicity to a culturable human pathogen and gene therapy vector candidate.Clinical microbiology reviews · 2025Review
- MA104 cell line is permissive for human bocavirus 1 infection.Journal of virology · 2025Article
- Comparison of MT-PCR with Quantitative PCR for Human Bocavirus in Respiratory Samples with Multiple Respiratory Viruses Detection.Diagnostics (Basel, Switzerland) · 2023Article
- Highly Sensitive Multiplex Detection of Molecular Biomarkers Using Hybridization Chain Reaction in an Encoded Particle Microfluidic Platform.Biosensors · 2023Article
- The Large Nonstructural Protein (NS1) of Human Bocavirus 1 Directly Interacts with Ku70, Which Plays an Important Role in Virus Replication in Human Airway Epithelia.Journal of virology · 2022Article
- Human Bocavirus 1 Infection of Well-Differentiated Human Airway Epithelium.Current protocols in microbiology · 2020Article
- Human Bocavirus in Brazil: Molecular Epidemiology, Viral Load and Co-Infections.Pathogens (Basel, Switzerland) · 2020Article
- Current and Future Point-of-Care Tests for Emerging and New Respiratory Viruses and Future Perspectives.Frontiers in cellular and infection microbiology · 2020Review
- Comparison of phenotypic and genotypic diagnosis of acute human bocavirus 1 infection in children.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2019Article
- Human adenovirus replication and persistence in hypertrophic adenoids and palatine tonsils in children.Journal of medical virology · 2019Article
- Human Bocavirus: Detection, Quantification and Molecular Characterization in Sewage and Surface Waters in Uruguay.Food and environmental virology · 2018Article
- Novel Parvoviruses from Wild and Domestic Animals in Brazil Provide New Insights into Parvovirus Distribution and Diversity.Viruses · 2018Article
- Prevalence of Human Bocavirus in Africa and Other Developing Countries between 2005 and 2016: A Potential Emerging Viral Pathogen for Diarrhea.Journal of tropical medicine · 2018Review
- Human Bocavirus Capsid Messenger RNA Detection in Children With Pneumonia.The Journal of infectious diseases · 2017Article
- [Relationship between viral load of human bocavirus and clinical characteristics in children with acute lower respiratory tract infection].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Human Parvoviruses.Clinical microbiology reviews · 2017Review
- DNA Damage Signaling Is Required for Replication of Human Bocavirus 1 DNA in Dividing HEK293 Cells.Journal of virology · 2017Article
- B-Cell Responses to Human Bocaviruses 1-4: New Insights from a Childhood Follow-Up Study.PloS one · 2015Article
- Respiratory viruses are continuously detected in children with chronic tonsillitis throughout the year.International journal of pediatric otorhinolaryngology · 2014Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human bocavirus (HBoV) is a parvovirus recently identified in association with acute respiratory infections (ARI). Despite its worldwide occurrence, little is known on the pathogenesis of HBoV infections. In addition, few systematic studies of HBoV in ARI have been conducted in Latin America. Therefore, in order to test whether active viral replication of human bocavirus is associated with respiratory diseases and to understand the clinical impact of this virus in patients with these diseases, we performed a 3-year retrospective hospital-based study of HBoV in outpatients and inpatients with symptoms of Acute Respiratory Infections (ARI) in Brazil. Nasopharyngeal aspirates (NPAs) from 1015 patients with respiratory symptoms were tested for HBoV DNA by PCR. All samples positive for HBoV were tested by PCR for all other respiratory viruses, had HBoV viral loads determined by quantitative real time PCR and, when possible, were tested by RT-PCR for HBoV VP1 mRNA, as evidence of active viral replication. HBoV was detected in 4.8% of patients, with annual rates of 10.0%, 3.0% and 3.0% in 2005, 2006 and 2007, respectively. The range of respiratory symptoms was similar between HBoV-positive and HBoV-negative ARI patients. However, a higher rate of diarrhea was observed in HBoV-positive patients. High HBoV viral loads (>10⁸ copies/mL) and diarrhea were significantly more frequent in patients with exclusive infection by HBoV and in patients with detection of HBoV VP1 mRNA than in patients with viral co-infection, detected in 72.9% of patients with HBoV. In summary, our data demonstrated that active HBoV replication was detected in a small percentage of patients with ARI and was correlated with concurrent diarrhea and lack of other viral co-infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.