ArticlePloS one2011
ELOVL6 genetic variation is related to insulin sensitivity: a new candidate gene in energy metabolism.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Chromosome-level genome provides new insights into the fatty acid biosynthesis and metabolism of the sea urchin Strongylocentrotus intermedius.BMC genomics · 2026Article
- Low expression of ELOVL6 may be involved in fat loss in white adipose tissue of cancer-associated cachexia.Lipids in health and disease · 2024Article
- ZebrafishFrontiers in cell and developmental biology · 2024Article
- Quantile-Dependent Heritability of Glucose, Insulin, Proinsulin, Insulin Resistance, and Glycated Hemoglobin.Lifestyle genomics · 2022Article
- Role of fatty acid elongase Elovl6 in the regulation of energy metabolism and pathophysiological significance in diabetes.Diabetology international · 2021Review
- Influence of Single Nucleotide Polymorphisms of ELOVL on Biomarkers of Metabolic Alterations in the Mexican Population.Nutrients · 2020Article
- Quantitative Phosphoproteomic Analysis Reveals the Regulatory Networks ofInternational journal of molecular sciences · 2020Article
- The elongation of very long-chain fatty acid 6 gene product catalyses elongation ofThe British journal of nutrition · 2019Article
- Gene-centric analysis implicates nuclear encoded mitochondrial protein gene variants in migraine susceptibility.Molecular genetics & genomic medicine · 2017Article
- Epidermal growth factor gene is a newly identified candidate gene for gout.Scientific reports · 2016Article
- Crucial Role of Elovl6 in Chondrocyte Growth and Differentiation during Growth Plate Development in Mice.PloS one · 2016Article
- A novel approach to identify optimal metabotypes of elongase and desaturase activities in prevention of acute coronary syndrome.Metabolomics : Official journal of the Metabolomic Society · 2015Article
- A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance.The Journal of biological chemistry · 2014Article
- Central Role of the PPARγ Gene Network in Coordinating Beef Cattle Intramuscular Adipogenesis in Response to Weaning Age and Nutrition.Gene regulation and systems biology · 2014Article
- Fatty acid metabolism: Implications for diet, genetic variation, and disease.Food bioscience · 2013Article
- Genetic analysis of the ELOVL6 gene polymorphism associated with type 2 diabetes mellitus.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- Article
- Eicosanoids in metabolic syndrome.Advances in pharmacology (San Diego, Calif.) · 2013Review
- Polymorphism in the ELOVL6 gene is associated with a major QTL effect on fatty acid composition in pigs.PloS one · 2013Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe elongase of long chain fatty acids family 6 (ELOVL6) is an enzyme that specifically catalyzes the elongation of saturated and monounsaturated fatty acids with 12, 14 and 16 carbons. ELOVL6 is expressed in lipogenic tissues and it is regulated by sterol regulatory element binding protein 1 (SREBP-1).
objectiveWe investigated whether ELOVL6 genetic variation is associated with insulin sensitivity in a population from southern Spain.
designWe undertook a prospective, population-based study collecting phenotypic, metabolic, nutritional and genetic information. Measurements were made of weight and height and the body mass index (BMI) was calculated. Insulin resistance was measured by homeostasis model assessment. The type of dietary fat was assessed from samples of cooking oil taken from the participants' kitchens and analyzed by gas chromatography. Five SNPs of the ELOVL6 gene were analyzed by SNPlex.
resultsCarriers of the minor alleles of the SNPs rs9997926 and rs6824447 had a lower risk of having high HOMA_IR, whereas carriers of the minor allele rs17041272 had a higher risk of being insulin resistant. An interaction was detected between the rs6824447 polymorphism and the intake of oil in relation with insulin resistance, such that carriers of this minor allele who consumed sunflower oil had lower HOMA_IR than those who did not have this allele (P = 0.001).
conclusionsGenetic variations in the ELOVL6 gene were associated with insulin sensitivity in this population-based study.
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