ArticleObesity (Silver Spring, Md.)2011
A genome-wide association study of BMI in American Indians.
Article in Obesity (Silver Spring, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- New susceptibility loci associated with kidney disease in type 1 diabetes.PLoS genetics · 2012Pooled it
- Identification of shared genetic susceptibility locus for coronary artery disease, type 2 diabetes and obesity: a meta-analysis of genome-wide studies.Cardiovascular diabetology · 2012Pooled it
- Genetic associations with disease in populations with Indigenous American ancestries.Genetics and molecular biology · 2024Article
- Characterization of Exome Variants and Their Metabolic Impact in 6,716 American Indians from the Southwest US.American journal of human genetics · 2020Article
- Analysis of type 2 diabetes and obesity genetic variants in Mexican Pima Indians: Marked allelic differentiation among Amerindians at HLA.Annals of human genetics · 2018Article
- Functional implications of Neandertal introgression in modern humans.Genome biology · 2017Article
- Selecting SNPs informative for African, American Indian and European Ancestry: application to the Family Investigation of Nephropathy and Diabetes (FIND).BMC genomics · 2016Article
- Assessing FOXO1A as a potential susceptibility locus for type 2 diabetes and obesity in American Indians.Obesity (Silver Spring, Md.) · 2015Article
- A cis-eQTL in PFKFB2 is associated with diabetic nephropathy, adiposity and insulin secretion in American Indians.Human molecular genetics · 2015Article
- Study design of the Maycoba Project: obesity and diabetes in Mexican Pimas.American journal of health behavior · 2014Article
- Article
- A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes.Diabetes · 2014Article
- MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation.Human molecular genetics · 2013Article
- Epidemiology and genetic determinants of progressive deterioration of glycaemia in American Indians: the Strong Heart Family Study.Diabetologia · 2013Article
- Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate.Journal of human genetics · 2013Observational
- Identification of genetic variation that determines human trehalase activity and its association with type 2 diabetes.Human genetics · 2013Article
- 'Metabolically healthy obesity': origins and implications.Molecular aspects of medicine · 2013Review
- Article
- Evidence for a role of LPGAT1 in influencing BMI and percent body fat in Native Americans.Obesity (Silver Spring, Md.) · 2013Article
- Variants in the LEPR gene are nominally associated with higher BMI and lower 24-h energy expenditure in Pima Indians.Obesity (Silver Spring, Md.) · 2012Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Numerous studies have been done to understand genetic contributors to BMI, but only a limited number of studies have been done in nonwhite groups such as American Indians. A genome-wide association study (GWAS) for BMI was therefore performed in Pima Indians. BMI measurements from a longitudinal study of 1,120 Pima Indians and 454,194 single-nucleotide polymorphisms (SNPs) from the 1 million Affymetrix SNP panel were used (35% of SNPs were excluded due to minor allele frequency <0.05). Data included BMI measured at multiple examinations collected from 1965 to 2004, as well as the maximum BMI at one of these visits. General and within-family tests were performed using a maximum-likelihood based mixed model procedure. No SNP reached a genome-wide significance level (estimated at P < 4.94 × 10(-7)). For repeated measures analyses, the strongest associations for general and within-family tests mapped to two different regions on chromosome 6 (rs9342220 (P = 1.39 × 10(-6)) and rs7758764 (P = 2.51 × 10(-6)), respectively). For maximum BMI, the strongest association for the general tests mapped to chromosome 4 (rs17612333; P = 1.98 × 10(-6)) and to chromosome 3 (rs11127958; P = 1.53 × 10(-6)) for the within-family tests. Further analysis is important because only a few of these regions have been previously implicated in a GWAS and genetic susceptibility may differ by ethnicity.
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