ArticleThe EMBO journal2011
A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity.
Article in The EMBO journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- From transporter to motor: Evolutionary and structural insights into the emergence of prestin's area-motor activity in mammals.Protein science : a publication of the Protein Society · 2026Article
- Piezoelectric Biomaterials for Osteochondral Tissue Engineering: Advances, Mechanisms, and Translational Prospects.Journal of functional biomaterials · 2026Review
- Enhancing prestin oligomerization for superior sonogenetics.Theranostics · 2026Article
- Folding of prestin's anion-binding site and the mechanism of outer hair cell electromotility.eLife · 2023Article
- Elevator-like movements of prestin mediate outer hair cell electromotility.Nature communications · 2023Article
- Prestin-Mediated Frequency Selectivity Does not Cover Ultrahigh Frequencies in Mice.Neuroscience bulletin · 2022Article
- Molecular convergence and transgenic evidence suggest a single origin of laryngeal echolocation in bats.iScience · 2022Article
- Article
- Comparative Molecular Dynamics Investigation of the Electromotile Hearing Protein Prestin.International journal of molecular sciences · 2021Article
- Outer Hair Cells and Electromotility.Cold Spring Harbor perspectives in medicine · 2019Review
- Structural basis for functional interactions in dimers of SLC26 transporters.Nature communications · 2019Article
- Genomic and functional evidence reveals molecular insights into the origin of echolocation in whales.Science advances · 2018Article
- The extracellular loop of pendrin and prestin modulates their voltage-sensing property.The Journal of biological chemistry · 2018Article
- The R130S mutation significantly affects the function of prestin, the outer hair cell motor protein.Journal of molecular medicine (Berlin, Germany) · 2016Article
- Prestin and the good vibrations.The Biochemical journal · 2016Article
- Chloride Anions Regulate Kinetics but Not Voltage-Sensor Qmax of the Solute Carrier SLC26a5.Biophysical journal · 2016Article
- The chloride-channel blocker 9-anthracenecarboxylic acid reduces the nonlinear capacitance of prestin-associated charge movement.The European journal of neuroscience · 2016Article
- Glutamate transporter homolog-based model predicts that anion-π interaction is the mechanism for the voltage-dependent response of prestin.The Journal of biological chemistry · 2015Article
- Prestin is an anion transporter dispensable for mechanical feedback amplification in Drosophila hearing.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Article
- Prestin at year 14: progress and prospect.Hearing research · 2014Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prestin, a transporter-like protein of the SLC26A family, acts as a piezoelectric transducer that mediates the fast electromotility of outer hair cells required for cochlear amplification and auditory acuity in mammals. Non-mammalian prestin orthologues are anion transporters without piezoelectric activity. Here, we generated synthetic prestin (SynPres), a chimera of mammalian and non-mammalian prestin exhibiting both, piezoelectric properties and anion transport. SynPres delineates two distinct domains in the protein's transmembrane core that are necessary and sufficient for generating electromotility and associated non-linear charge movement (NLC). Functional analysis of SynPres showed that the amplitude of NLC and hence electromotility are determined by the transport of monovalent anions. Thus, prestin-mediated electromotility is a dual-step process: transport of anions by an alternate access cycle, followed by an anion-dependent transition generating electromotility. The findings define structural and functional determinants of prestin's piezoelectric activity and indicate that the electromechanical process evolved from the ancestral transport mechanism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.