Evidence map›Paper›PMID 21701522›Full record

ReviewNature reviews. Immunology2011

Signal integration and crosstalk during thymocyte migration and emigration.

Paul E Love, Avinash Bhandoola

Abstract readReview
In one paragraph

Review in Nature reviews. Immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

118 citing papers in PubMed.

  1. Mesenchymal cells rebuild the thymus.Nature biotechnology · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. The dual nature of TFEBS letters · 2025
    Review
  10. The Ins and Outs of Thymic Epithelial Cell Differentiation and Function.Advances in experimental medicine and biology · 2025
    Review
  11. Article
  12. Cystathionine γ-lyase-derived HActa pharmacologica Sinica · 2024
    Article
  13. Transcriptional network dynamics in early T cell development.The Journal of experimental medicine · 2024
    Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. A spatial human thymus cell atlas mapped to a continuous tissue axis.bioRxiv : the preprint server for biology · 2023
    Article
  20. Article

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Paul E LoveEunice Kennedy Schriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. lovep@mail.nih.gov
Avinash Bhandoola

Funding

Genes and signals controlling mammalian hematopoiesis.ZIAHD001803 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI LOVE, PAUL E · 2009 to 2025
$36.9M
Early T lineage progenitorsR01AI059621 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BHANDOOLA, AVINASH · 2004 to 2013
$3.5M
Migration of hematopoietic progenitors to the thymusR01HL110741 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GREENE, MARK I · 2011 to 2014
$1.5M
Engineering hematopoietic progenitors for efficient migration to the thymusRC1HL099758 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BHANDOOLA, AVINASH · 2009 to 2010
$1.0M
Early T Lineage ProgenitorsR56AI059621 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI GREENE, MARK I · 2014 to 2014
$400k
Signals directing the migration of hematopoietic progenitor into the thymusR21HL086900 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI BHANDOOLA, AVINASH · 2007 to 2008
$394k
Intramural NIH HHS Z99 DA999999Intramural NIH HHS Z99 HD999999Intramural NIH HHS Z99 HL999999Intramural NIH HHS Z99 MH999999Intramural NIH HHS Z99 OD999999Intramural NIH HHS ZIA HD001803NHLBI NIH HHS R01 HL110741NHLBI NIH HHS R21 HL086900NHLBI NIH HHS RC1 HL099758NHLBI NIH HHS RC1HL099758NIAID NIH HHS AI059621NIAID NIH HHS R01 AI059621
6 · The paper itself

Abstract

The thymus produces self-tolerant functionally competent T cells. This process involves the import of multipotent haematopoietic progenitors that are then signalled to adopt the T cell fate. Expression of T cell-specific genes, including those encoding the T cell receptor (TCR), is followed by positive and negative selection and the eventual export of mature T cells. Significant progress has been made in elucidating the signals that direct progenitor cell trafficking to, within and out of the thymus. These advances are the subject of this Review, with a particular focus on the role of reciprocal cooperative and regulatory interactions between TCR- and chemokine receptor-mediated signalling.

Indexed as

AnimalsCell MovementHumansModels, ImmunologicalReceptors, Antigen, T-CellReceptors, ChemokineSignal TransductionStem CellsThymus GlandT-LymphocytesReceptors, Antigen, T-CellReceptors, Chemokine

Identifiers

PMID21701522
PMCPMC3710714

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.