ArticleShock (Augusta, Ga.)2011
The outcome of polymicrobial sepsis is independent of T and B cells.
Article in Shock (Augusta, Ga.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- IL-27 Enhances γδ T Cell-Mediated Innate Resistance to Primary Hookworm Infection in the Lungs.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Bacterial polyphosphates interfere with the innate host defense to infection.Nature communications · 2020Article
- Experimental design of complement component 5a-induced acute lung injury (C5a-ALI): a role of CC-chemokine receptor type 5 during immune activation by anaphylatoxin.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Potential role of myeloid cell/eosinophil-derived IL-17 in LPS-induced endotoxin shock.Biochemical and biophysical research communications · 2014Article
- Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27.Journal of leukocyte biology · 2014Article
- Article
- WAVE1 mediates suppression of phagocytosis by phospholipid-derived DAMPs.The Journal of clinical investigation · 2013Article
- The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation.European journal of immunology · 2013Article
- Candida albicans-Staphylococcus aureus polymicrobial peritonitis modulates host innate immunity.Infection and immunity · 2013Article
- CD11c+ alveolar macrophages are a source of IL-23 during lipopolysaccharide-induced acute lung injury.Shock (Augusta, Ga.) · 2013Article
- Regulation of IL-17 family members by adrenal hormones during experimental sepsis in mice.The American journal of pathology · 2013Article
- Regulatory T cells are protective in systemic inflammation response syndrome induced by zymosan in mice.PloS one · 2013Article
- Fingerprinting of the TLR4-induced acute inflammatory response.Experimental and molecular pathology · 2012Article
- Th17 cells: critical mediators of host responses to burn injury and sepsis.Journal of leukocyte biology · 2012Review
- A historical perspective on sepsis.The American journal of pathology · 2012Review
- Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Anti-inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- New insights for C5a and C5a receptors in sepsis.Frontiers in immunology · 2012Article
- MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The contribution of the adaptive and innate immune systems to the pathogenesis and outcome of sepsis remains a fundamental yet controversial question. Here, we use mice lacking the recombination activating gene 1 (Rag-1) to study the role of T and B cells in sepsis after cecal ligation and puncture (CLP). Spleens of Rag-1 mice were atrophic and completely devoid of CD3 T cells and CD19 B cells. Wild-type mice and Rag-1 mice (both on a C57BL/6J background) underwent CLP or sham surgery. Both wild-type and Rag-1 mice developed clinical signs of sepsis within the first day after CLP. This included severe hypothermia as measured by a decrease in body surface temperature and organ dysfunction as detected by plasma increases in blood urea nitrogen and lactate dehydrogenase levels. Survival curves of wild-type and Rag-1 mice after CLP were superimposable, with 35% survival in the wild-type group and 27% survival in the Rag-1 group, respectively (not significant, P = 0.875). Using multiplex bead-based assays, the mediator concentrations for 23 cytokines and chemokines were measured in plasma of wild-type and Rag-1 mice 8 h after CLP or sham surgery. Compared with sham surgery mice, the highest mediator levels were observed for granulocyte colony-stimulating factor, keratinocyte chemoattractant, IL-6, monocyte chemotactic protein 1, and IL-10. Levels for most mediators were unaffected by the absence of T and B lymphocytes. Only the concentrations of IL-6 and IL-17 were found to be significantly lower in Rag-1 mice compared with wild-type mice. In conclusion, the absence of T and B cells in the CLP model used does not appear to affect the acute outcome of severe sepsis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.