ReviewEuropean journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)2011
The maternal womb: a novel target for cancer prevention in the era of the obesity pandemic?
Review in European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Soy isoflavone consumption and colorectal cancer risk: a systematic review and meta-analysis.Scientific reports · 2016Pooled it
- Dietary supplementation with polyunsaturated fatty acid during pregnancy modulates DNA methylation at IGF2/H19 imprinted genes and growth of infants.Physiological genomics · 2014Trial
- Maternal diet in pregnancy and acute leukemia in infants: a case-control study in Mexico City.Frontiers in oncology · 2023Article
- Article
- Fetal Alcohol Exposure Alters Mammary Epithelial Cell Subpopulations and Promotes Tumorigenesis.Alcoholism, clinical and experimental research · 2020Article
- Chronic inflammation in the etiology of disease across the life span.Nature medicine · 2019Review
- Epigenetic Gene Regulation by Dietary Compounds in Cancer Prevention.Advances in nutrition (Bethesda, Md.) · 2019Article
- Maternal Obesity, Birth Size, and Risk of Childhood Cancer Development.American journal of epidemiology · 2019Article
- Pregnancy-associated breast cancer: the risky status quo and new concepts of predictive medicine.The EPMA journal · 2018Review
- Placental Ras Regulates Inflammation Associated with Maternal Obesity.Mediators of inflammation · 2018Article
- Maternal pre-pregnancy and gestational diabetes, obesity, gestational weight gain, and risk of cancer in young children: a population-based study in California.Cancer causes & control : CCC · 2016Article
- Metabolic history impacts mammary tumor epithelial hierarchy and early drug response in mice.Endocrine-related cancer · 2016Article
- Tumor Phenotype and Gene Expression During Early Mammary Tumor Development in Offspring Exposed to Alcohol In Utero.Alcoholism, clinical and experimental research · 2016Article
- Maternal Obesity and its Short- and Long-Term Maternal and Infantile Effects.Journal of clinical research in pediatric endocrinology · 2016Review
- Effects of obesity on hormonally driven cancer in women.Science translational medicine · 2016Review
- Maternal metabolic perturbations elicited by high-fat diet promote Wnt-1-induced mammary tumor risk in adult female offspring via long-term effects on mammary and systemic phenotypes.Carcinogenesis · 2014Article
- Maternal preconception body mass index and offspring cord blood DNA methylation: exploration of early life origins of disease.Environmental and molecular mutagenesis · 2014Article
- Suppression of Wnt1-induced mammary tumor growth and lower serum insulin in offspring exposed to maternal blueberry diet suggest early dietary influence on developmental programming.Carcinogenesis · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
The dramatic rise in worldwide prevalence of obesity has necessitated the search for more efficacious antiobesity strategies to counter the increased cancer risks in overweight and obese individuals. The mechanistic pathways linking obesity status with adult chronic diseases such as cancer remain incompletely understood. A growing body of evidence suggests that novel approaches and interventional agents to disrupt the feed-forward cycle of maternal to offspring obesity transfer that is initiated in utero will be important for stemming both the obesity pandemic and the associated increase in cancer incidence. The convergence of multiple research areas including those encompassing the insulin and insulin-like growth factor systems, epigenetics, and stem cell biology is providing insights into the potential for cancer prevention in adult offspring previously exposed to the intrauterine environment of overweight/obese mothers. Here, we review the current state of this nascent research field, with a focus on three major cancers, namely breast, colorectal, and liver, and suggest some possible future directions to optimize its impact for the health of future generations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.