ArticlePlastic and reconstructive surgery2011
Dose-response effect of human equivalent radiation in the murine mandible: part I. A histomorphometric assessment.
Article in Plastic and reconstructive surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Mitophagy activation for jawbone radiation injury therapy via angiogenesis/osteogenesis-active nanozymes.Science China. Life sciences · 2026Article
- Protective effect of Carica papaya leaf extract against dental pulp damage induced by gamma irradiation.Journal of molecular histology · 2025Article
- Intraoperative Optimization of Stromal Vascular Fraction for Remediation of Radiated Fracture Repair: Closing the Gap on Clinical Translation of Cell-Based Therapies.Annals of plastic surgery · 2025Article
- Effects of different doses of ionizing radiation on alveolar bone repair in post-extraction tooth socket: an experimental study in rats.Clinical oral investigations · 2023Article
- Effects of different irradiators on the establishment of osteoradionecrosis model of rat mandible.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021Article
- Overcoming Nuclear Winter: The Cutting-edge Science of Bone Healing and Regeneration in Irradiated Fields.Plastic and reconstructive surgery. Global open · 2021Article
- Development of a standardized mucositis and osteoradionecrosis animal model using external radiation.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2020Article
- Effect of α2‑macroglobulin in the early stage of jaw osteoradionecrosis.International journal of oncology · 2020Article
- Noncultured Minimally Processed Adipose-Derived Stem Cells Improve Radiated Fracture Healing.Annals of plastic surgery · 2020Article
- Implantable hyaluronic acid-deferoxamine conjugate prevents nonunions through stimulation of neovascularization.NPJ Regenerative medicine · 2019Article
- Radioprotection With Amifostine Enhances Bone Strength and Regeneration and Bony Union in a Rat Model of Mandibular Distraction Osteogenesis.Annals of plastic surgery · 2018Article
- Significant Differences in the Bone of an Isogenic Inbred Versus Nonisogenic Outbred Murine Mandible: A Study in Rigor and Reproducibility.The Journal of craniofacial surgery · 2017Article
- Translational treatment paradigm for managing non-unions secondary to radiation injury utilizing adipose derived stem cells and angiogenic therapy.Head & neck · 2016Article
- Targeting angiogenesis as a therapeutic means to reinforce osteocyte survival and prevent nonunions in the aftermath of radiotherapy.Head & neck · 2015Article
- Amifostine preserves osteocyte number and osteoid formation in fracture healing following radiotherapy.Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2014Article
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- Amifostine protects vascularity and improves union in a model of irradiated mandibular fracture healing.Plastic and reconstructive surgery · 2013Article
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- Dose-response effect of human equivalent radiation in the mandible.The Journal of craniofacial surgery · 2013Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe authors' laboratory previously demonstrated that radiation significantly alters new bone formation in the murine mandible, impeding the use of distraction osteogenesis as a viable reconstructive option after radiotherapy in head and neck cancer. The authors hypothesize that the deleterious effects of radiation on regenerate formation results from a dose-response depletion of essential osteogenic cells. The authors' specific aim was to use quantitative histomorphometry to objectively measure the human equivalent dose-response effects of radiation on the integrity of the mandible's cellular and tissue composition.
methodsTwenty Sprague-Dawley rats were randomized into three radiation dosage groups: low (5.91 Gy), middle (7 Gy), and high (8.89 Gy), delivered in five daily fractions. These dosages approximated 75, 100, and 150 percent, respectively, of the biological equivalent dose the mandible experiences in the clinical regimen of head and neck cancer patients. Hemimandibles were harvested 56 days after radiation and stained with Gomori trichrome. Quantitative histomorphometry was performed using Bioquant software and analysis with a one-way analysis of variance Kruskal-Wallis test.
resultsThe authors' data revealed a statistically significant diminution in the mean number of osteocytes. The authors also demonstrated a corresponding significant increase in the mean values of empty lacunae. Both of these quantitative histomorphometric changes demonstrated a dose-response relationship.
conclusionsThe authors' study supports their hypothesis that radiation induces a dose-response depletion in osteocytes and an increase in empty lacunae. These reliable and reproducible metrics can now be used to determine the efficacy of therapies aimed at safeguarding the cells essential for optimal bone regeneration and potentially enhance the use of distraction osteogenesis in head and neck cancer patients.
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