Evidence map›Paper›PMID 21701259›Full record

ReviewPlant signaling & behavior2011

Modulation of plant HMG-CoA reductase by protein phosphatase 2A: positive and negative control at a key node of metabolism.

Meritxell Antolín-Llovera, Pablo Leivar, Montserrat Arró, Albert Ferrer, Albert Boronat, Narciso Campos

Open access · bronzeAbstract readReview
In one paragraph

Review in Plant signaling & behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. The Influence of the Non-PathogenicInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Comprehensive genome-wide analysis of theFrontiers in plant science · 2025
    Article
  6. Article
  7. Isolation ofGenes · 2022
    Article
  8. Article
  9. Article
  10. Overexpression ofInternational journal of molecular sciences · 2019
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Meritxell Antolín-LloveraDepartament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain.
Pablo Leivar
Montserrat Arró
Albert Ferrer
Albert Boronat
Narciso Campos
Institut de Biologia Molecular de Barcelona · ESUniversitat de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The enzyme HMG-CoA reductase (HMGR) has a key regulatory role in the mevalonate pathway for isoprenoid biosynthesis, critical not only for normal plant development, but also for the adaptation to demanding environmental conditions. Consistent with this notion, plant HMGR is modulated by many diverse endogenous signals and external stimuli. Protein phosphatase 2A (PP2A) is involved in auxin, abscisic acid, ethylene and brassinosteroid signaling and now emerges as a positive and negative multilevel regulator of plant HMGR, both during normal growth and in response to a variety of stress conditions. The interaction with HMGR is mediated by B" regulatory subunits of PP2A, which are also calcium binding proteins. The new discoveries uncover the potential of PP2A to integrate developmental and calcium-mediated environmental signals in the control of plant HMGR.

Indexed as

CalciumCalcium-Binding ProteinsHydroxymethylglutaryl CoA ReductasesPlant ProteinsPlantsProtein Phosphatase 2CalciumCalcium-Binding ProteinsHydroxymethylglutaryl CoA ReductasesPlant ProteinsProtein Phosphatase 2

Identifiers

PMID21701259
PMCPMC3260709
OpenAlexW2056793101

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.