ArticleThe EMBO journal1990
The physical organization of the human immunoglobulin heavy chain gene complex.
Article in The EMBO journal, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 115 citations in OpenAlex.
- Differential IgM expression distinguishes two types of pediatric Burkitt lymphoma in mouse and human.Oncotarget · 2016Article
- The immunoglobulin heavy chain locus: genetic variation, missing data, and implications for human disease.Genes and immunity · 2012Review
- Direct detection of insertion/deletion polymorphisms in an autosomal region by analyzing high-density markers in individual spermatozoa.American journal of human genetics · 2002Article
- Clinical and molecular analysis of patients with defects in micro heavy chain gene.The Journal of clinical investigation · 2002Article
- Origin and diversification of the clonogenic cell in multiple myeloma: lessons from the immunoglobulin repertoire.Leukemia · 2000Review
- Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes.The Journal of experimental medicine · 2000Article
- The super-information age of immunoglobulin genetics.The Journal of experimental medicine · 1998Article
- Determination of gene organization in individual haplotypes by analyzing single DNA fragments from single spermatozoa.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Lack of intraclonal diversification in Ig heavy and light chain V region genes expressed by CD5+IgM+ chronic lymphocytic leukemia B cells: a multiple time point analysis.Journal of immunology (Baltimore, Md. : 1950) · 1998Article
- VH-mediated mechanisms in normal and neoplastic B cell development.Immunologic research · 1998Review
- Lack of allelic exclusion in B cell chronic lymphocytic leukemia.The Journal of experimental medicine · 1997Article
- VHDJH gene sequences and antigen reactivity of monoclonal antibodies produced by human B-1 cells: evidence for somatic selection.Journal of immunology (Baltimore, Md. : 1950) · 1997Article
- The human immunoglobulin V(H) gene repertoire is genetically controlled and unaltered by chronic autoimmune stimulation.The Journal of clinical investigation · 1996Article
- The immunoglobulin heavy-chain variable region in insulin-dependent diabetes mellitus: affected-sib-pair analysis and association studies.American journal of human genetics · 1996Article
- Expression of the immunoglobulin VH gene 51p1 is proportional to its germline gene copy number.The Journal of clinical investigation · 1996Article
- Analysis of human monoclonal antibodies elicited by vaccination with a Cryptococcus neoformans glucuronoxylomannan capsular polysaccharide vaccine.Infection and immunity · 1995Article
- Molecular analysis redefines three human chromosome 14 deletions.Human genetics · 1995Article
- The study of minimal residual disease in acute lymphoblastic leukaemia.Clinical molecular pathology · 1995Article
- The immunoglobulin heavy chain and disease association: application to pemphigus vulgaris.Human genetics · 1994Article
- HAPPY mapping of a YAC reveals alternative haplotypes in the human immunoglobulin VH locus.Nucleic acids research · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two dimensional DNA electrophoresis (2D-DE) was used to map the variable (VH) region of the human heavy chain immunoglobulin gene cluster. Seventy-six VH gene segments were mapped to specific SfiI, BssHI and NotI fragments by 2D-DE. We have determined that a common insertion/deletion polymorphism of 80 kb, involving three VH gene segments, occurs in the VH region. The physical map suggests that the evolution of the human IGH gene complex involved duplication of blocks containing different VH families. This physical map will allow comparison of the usage of VH loci in human ontogeny with their proximity to the CH region. Knowledge of the germline repertoire of a particular DNA source studied in essential as the number of the dispersed VH gene segments of VH families, especially of the VH5 family, is variable. 2D-DE, as illustrated here for the IGH gene cluster, has general application in the development of large scale physical maps of gene and repeat families.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.