ArticleAJR. American journal of roentgenology2011
Dynamic postprandial hepatic stiffness augmentation assessed with MR elastography in patients with chronic liver disease.
Article in AJR. American journal of roentgenology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 1 of them a synthesis that pooled it.
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Who cites it
63 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Repeatability of MR Elastography of Liver: A Meta-Analysis.Radiology · 2017Pooled it
- Assessment of portal hypertension and high-risk oesophageal varices with liver and spleen three-dimensional multifrequency MR elastography in liver cirrhosis.European radiology · 2014Trial
- Non-invasive evaluation of liver fibrosis: a comparison of ultrasound-based transient elastography and MR elastography in patients with viral hepatitis B and C.European radiology · 2014Trial
- Application of the three-phase T1-derived model in staging liver fibrosis in chronic hepatitis: a comparative study with magnetic resonance elastography.Abdominal radiology (New York) · 2025Article
- Shear wave elastography primer for the abdominal radiologist.Abdominal radiology (New York) · 2025Review
- Liver stiffness measurements in patients with metabolic dysfunction-associated steatotic liver disease: Updates on the method effectiveness and perspectives.World journal of hepatology · 2025Review
- Magnetic Resonance Elastography of Upper Trapezius Muscle.NMR in biomedicine · 2025Article
- Wavelet MRE: Imaging propagating broadband acoustic waves with wavelet-based motion-encoding gradients.Magnetic resonance in medicine · 2024Article
- MR Elastography: Practical Questions, From theAJR. American journal of roentgenology · 2024Review
- Liver fibrosis assessment: MR and US elastography.Abdominal radiology (New York) · 2022Review
- Fc receptor-like 5 gene polymorphisms and mRNA expression are associated with liver fibrosis in chronic hepatitis B.Frontiers in microbiology · 2022Article
- Magnetic resonance elastography of the liver: everything you need to know to get started.Abdominal radiology (New York) · 2022Review
- On the relationship between metabolic capacities andFrontiers in bioengineering and biotechnology · 2022Article
- Updates on Quantitative MRI of Diffuse Liver Disease: A Narrative Review.BioMed research international · 2022Review
- Development of three-dimensional integral-type reconstruction formula for magnetic resonance elastography.International journal of computer assisted radiology and surgery · 2021Article
- Postprandial hepatic stiffness changes on magnetic resonance elastography in healthy volunteers.Scientific reports · 2021Article
- Using MR elastography to assess portal hypertension and response to beta-blockers in patients with cirrhosis.Liver international : official journal of the International Association for the Study of the Liver · 2021Article
- MR elastography: Principles, guidelines, and terminology.Magnetic resonance in medicine · 2021Review
- Magnetic resonance elastography to quantify liver disease severity in autosomal recessive polycystic kidney disease.Abdominal radiology (New York) · 2021Article
- Preliminary experience with 3T magnetic resonance elastography imaging of the liver.SA journal of radiology · 2021Article
3 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
objectiveMR elastography (MRE) is an MRI-based technique for quantitatively assessing tissue stiffness by studying shear wave propagation through tissue. The goal of this study was to test the hypothesis that hepatic MRE performed before and after a meal will result in a postprandial increase in hepatic stiffness among patients with hepatic fibrosis because of transiently increased portal pressure. SUBJECTS AND
methodsTwenty healthy volunteers and 25 patients with biopsyproven hepatic fibrosis were evaluated. Preprandial MRE measurements were performed after overnight fasting. A liquid test meal was administered, and 30 minutes later a postprandial MRE acquisition was performed. Identical imaging parameters and analysis regions of interest were used for pre- and postprandial acquisitions.
resultsThe results in the 20 subjects without liver disease showed a mean stiffness change of 0.16 ± 0.20 kPa (range, -0.12 to 0.78 kPa) or 8.08% ± 10.33% (range, -5.36% to 41.7%). The hepatic stiffness obtained in the 25 patients with hepatic fibrosis showed a statistically significant increase in postprandial liver stiffness, with mean augmentation of 0.89 ± 0.96 kPa (range, 0.17-4.15 kPa) or 21.24% ± 14.98% (range, 7.69%-63.3%).
conclusionMRE-assessed hepatic stiffness elevation in patients with chronic liver disease has two major components: a static component reflecting structural change or fibrosis and a dynamic component reflecting portal pressure that can increase after a meal. These findings will provide motivation for further studies to determine the potential value of assessing postprandial hepatic stiffness augmentation for predicting the progression of fibrotic disease and the development of portal hypertension. The technique may also provide new insights into the natural history and pathophysiology of chronic liver disease.
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