ArticleDiabetes care2011
Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: the prospective investigation of the vasculature in Uppsala Seniors (PIVUS) study.
Article in Diabetes care, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02675101 (Nuts and Olestra for Persistent Organic Pollutant Reduction), which is not on this map. Cited by 101 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nuts and Olestra for Persistent Organic Pollutant Reduction (NO-POPs) Trial: A Pilot Investigation
Who cites it
101 citing papers in PubMed, 6 syntheses or guidelines pooled it, 243 citations in OpenAlex.
- Association between DDT or its byproducts and T2DM: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- Endocrine-disrupting chemicals and the risk of gestational diabetes mellitus: a systematic review and meta-analysis.Environmental health : a global access science source · 2022Pooled it
- The association between environmental exposures to chlordanes, adiposity and diabetes-related features: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- Exposure to organochlorine pollutants and type 2 diabetes: a systematic review and meta-analysis.PloS one · 2014Pooled it
- Environmental chemicals and type 2 diabetes: an updated systematic review of the epidemiologic evidence.Current diabetes reports · 2013Pooled it
- Persistent organic pollutants and type 2 diabetes: a prospective analysis in the nurses' health study and meta-analysis.Environmental health perspectives · 2013Pooled it
- Organic Pollutants and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis.Mayo Clinic proceedings. Innovations, quality & outcomes · 2026Article
- Maternal factors associated with plasma concentrations of endocrine-disrupting persistent organic pollutants including PFAS among Hispanic women from pregnancy to the post-delivery period.Environment international · 2025Article
- Advanced photocatalytic degradation of POPs and other contaminants: a comprehensive review on nanocomposites and heterojunctions.RSC advances · 2025Review
- Persistent organochlorine pesticides and cardiometabolic outcomes among middle-aged Latina women in a California agricultural community: The CHAMACOS Maternal Cognition Study.Environment international · 2025Article
- Non-alcoholic fatty liver disease: Role of PNPLA3 and its association with environmental chemicals.Archives of clinical toxicology · 2024Article
- Update of the risk assessment of polybrominated diphenyl ethers (PBDEs) in food.EFSA journal. European Food Safety Authority · 2024Article
- Identification of PCB congeners and their thresholds associated with diabetes using decision tree analysis.Scientific reports · 2023Article
- Polybrominated Diphenyl Ethers (PBDEs) and Human Health: Effects on Metabolism, Diabetes and Cancer.Cancers · 2023Review
- Polychlorinated biphenyls, polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, pesticides, and diabetes in the Anniston Community Health Survey follow-up (ACHS II): single exposure and mixture analysis approaches.The Science of the total environment · 2023Article
- Identification of PCB Congeners and their Thresholds associated with Diabetes using Decision Tree Analysis.Research square · 2023Article
- A review on the application of the exposome paradigm to unveil the environmental determinants of age-related diseases.Human genomics · 2022Review
- The Association between Blood Concentrations of PCDD/DFs, DL-PCBs and the Risk of Type 2 Diabetes Mellitus and Thyroid Cancer in South Korea.International journal of environmental research and public health · 2022Article
- Persistent organic pollutants and β-cell toxicity: a comprehensive review.American journal of physiology. Endocrinology and metabolism · 2022Review
- Hydrogels and Hydrogel Nanocomposites: Enhancing Healthcare through Human and Environmental Treatment.Advanced healthcare materials · 2022Review
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePersistent organic pollutants (POPs), lipophilic chemicals that accumulate mainly in adipose tissue, have recently been linked to type 2 diabetes. However, evidence from prospective studies is sparse. This study was performed to evaluate prospective associations of type 2 diabetes with selected POPs among the elderly. RESEARCH DESIGN AND
methodsNineteen POPs (14 polychlorinated biphenyl [PCB] congeners, 3 organochlorine pesticides, 1 brominated diphenyl ether, and 1 dioxin) were measured in plasma collected at baseline in 725 participants, aged 70 years, of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS).
resultsAfter adjusting for known type 2 diabetes risk factors, including obesity, odds ratios (ORs) (95% CIs) for type 2 diabetes at age 75 years (n = 36) according to the quintiles of a summary measure of concentrations of PCBs (vs. the lowest quintile) were 4.5, 5.1, 8.8 (1.8-42.7), and 7.5 (1.4-38.8) (P(trend) <0.01). Among organochlorine pesticides, adjusted ORs across concentrations of trans-nonachlor showed that P(trend) = 0.03. Adjusted ORs (95% CIs) across quintiles of the sum of three organochlorine pesticides were 1.1, 1.6, 1.5, and 3.4 (1.0-11.7) (P(trend) = 0.03). Neither brominated diphenyl ether 47 nor dioxin was significantly associated with incident diabetes. The sum of PCBs improved reclassification significantly when added to traditional risk factors for diabetes.
conclusionsDespite the small number of incident cases, this study found that environmental exposure to some POPs substantially increased risk of future type 2 diabetes in an elderly population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.