SynthesisAmerican journal of respiratory and critical care medicine2011
Ozone and survival in four cohorts with potentially predisposing diseases.
Synthesis in American journal of respiratory and critical care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The effect of ambient ozone exposure on three types of diabetes: a meta-analysis.Environmental health : a global access science source · 2023Pooled it
- Long-term exposure to ambient ozone and mortality: a quantitative systematic review and meta-analysis of evidence from cohort studies.BMJ open · 2016Pooled it
- Systematic review and metaanalysis of air pollution exposure and risk of diabetes.European journal of epidemiology · 2014Pooled it
- Exposure to medium and high ambient levels of ozone causes adverse systemic inflammatory and cardiac autonomic effects.American journal of physiology. Heart and circulatory physiology · 2015Trial
- Long-term exposure to smoke PMEnvironment international · 2025Article
- Ozone exposure and cardiovascular disease: A narrative review of epidemiology evidence and underlying mechanisms.Fundamental research · 2025Review
- A Matter of Climate Justice: Heat and Air Pollution Combine to Worsen Effects of Homelessness.Environmental health perspectives · 2024Article
- Concurrent Heat and Air Pollution Exposures among People Experiencing Homelessness.Environmental health perspectives · 2024Article
- Antagonism between ambient ozone increase and urbanization-oriented population migration on Chinese cardiopulmonary mortality.Innovation (Cambridge (Mass.)) · 2023Article
- Long-term ambient air pollution exposure and cardio-respiratory disease in China: findings from a prospective cohort study.Environmental health : a global access science source · 2023Article
- Cohort-based long-term ozone exposure-associated mortality risks with adjusted metrics: A systematic review and meta-analysis.Innovation (Cambridge (Mass.)) · 2022Review
- Transcriptomics Underlying Pulmonary Ozone Pathogenesis Regulated by Inflammatory Mediators in Mice.Antioxidants (Basel, Switzerland) · 2021Article
- Ozone Exposure, Outdoor Physical Activity, and Incident Type 2 Diabetes in the SALSA Cohort of Older Mexican Americans.Environmental health perspectives · 2021Article
- Long-Term Exposure to Ambient Ozone and Progression of Subclinical Arterial Disease: The Multi-Ethnic Study of Atherosclerosis and Air Pollution.Environmental health perspectives · 2019Article
- Acute effects of air pollution on type II diabetes mellitus hospitalization in Shijiazhuang, China.Environmental science and pollution research international · 2018Article
- The Association Between PM2.5 and Ozone and the Prevalence of Diabetes Mellitus in the United States, 2002 to 2008.Journal of occupational and environmental medicine · 2018Article
- Pollution and respiratory disease: can diet or supplements help? A review.Respiratory research · 2018Review
- The effects of ozone on human health.Environmental science and pollution research international · 2018Article
- Updated Global Estimates of Respiratory Mortality in Adults ≥30Years of Age Attributable to Long-Term Ozone Exposure.Environmental health perspectives · 2017Article
- Airborne PMInternational journal of environmental research and public health · 2017Article
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2 authors.
Funding
Abstract
rationaleTime series studies have reported associations between ozone and daily deaths. Only one cohort study has reported the effect of long-term exposures on deaths, and little is known about effects of chronic ozone exposure on survival in susceptible populations.
objectivesWe investigated whether ozone was associated with survival in four cohorts of persons with specific diseases in 105 United States cities, treating ozone as a time varying exposure.
methodsWe used Medicare data (1985–2006), and constructed cohorts of persons hospitalized with chronic conditions that might predispose to ozone effects: chronic obstructive pulmonary disease, diabetes, congestive heart failure, and myocardial infarction. Yearly warm-season average ozone was merged to the individual follow-up in each city. We applied Cox proportional hazard model for each cohort within each city, adjusting for individual risk factors, temperature, and city-specific long-term trends. MEASUREMENTS AND MAIN
resultsWe found significant associations with a hazard ratio for mortality of 1.06 (95% confidence interval [CI], 1.03–1.08) per 5-ppb increase in summer average ozone for persons with congestive heart failure; of 1.09 (95% CI, 1.06–1.12) with myocardial infarction; of 1.07 (95% CI, 1.04–1.09) with chronic obstructive pulmonary disease; and of 1.07 (95% CI, 1.05–1.10) for diabetics.We also found that the effect varied by region, but that this was mostly explained by mean temperature, which is likely a surrogate of air conditioning use, and hence exposure.
conclusionsThis is the first study that follows persons with specific chronic conditions, and shows that long-term ozone exposure is associated with increased risk of death in these groups.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.