ArticleDiabetes2011
Higher cord C-peptide concentrations are associated with slower growth rate in the 1st year of life in girls but not in boys.
Article in Diabetes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- The Effect of Mild Gestational Diabetes Mellitus Treatment on Adverse Pregnancy Outcomes: A Systemic Review and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Glycemic control in gestational diabetes and impact on biomarkers in women and infants.Pediatric research · 2023Trial
- Umbilical cord blood concentration of connecting peptide (C-peptide) and pregnancy outcomes.BMC pregnancy and childbirth · 2022Trial
- Mild gestational diabetes mellitus and long-term child health.Diabetes care · 2015Trial
- Effect of maternal obesity with and without gestational diabetes on offspring subcutaneous and preperitoneal adipose tissue development from birth up to year-1.BMC pregnancy and childbirth · 2014Trial
- Maternal and fetal predictors of anthropometry in the first year of life in offspring of women with GDM.Frontiers in endocrinology · 2023Article
- Distinct cord blood C-peptide, adipokine, and lipidomic signatures by in utero HIV exposure.Pediatric research · 2022Article
- Article
- A Prospective Study to Determine if Management of Cases of Gestational Diabetes Mellitus (GDM) can be Modified.Journal of obstetrics and gynaecology of India · 2022Article
- Mediterranean diet during pregnancy and infant neurodevelopment: A prospective birth cohort study.Frontiers in nutrition · 2022Article
- Looking at the Future Through the Mother's Womb: Gestational Diabetes and Offspring Fertility.Endocrinology · 2021Review
- Increasing nausea and vomiting of pregnancy is associated with sex-dependent differences in early childhood growth: the GUSTO mother-offspring cohort study.BMC pregnancy and childbirth · 2021Article
- Intergenerational transmission of the effects of maternal exposure to childhood maltreatment on offspring obesity risk: A fetal programming perspective.Psychoneuroendocrinology · 2020Review
- Placental function in maternal obesity.Clinical science (London, England : 1979) · 2020Review
- Telomere length is reduced in 9- to 16-year-old girls exposed to gestational diabetes in utero.Diabetologia · 2018Article
- The Influence of Maternal Obesity and Breastfeeding on Infant Appetite- and Growth-Related Hormone Concentrations: The SKOT Cohort Studies.Hormone research in paediatrics · 2018Observational
- Effect of Maternal Factors and Fetomaternal Glucose Homeostasis on Birth Weight and Postnatal Growth.Journal of clinical research in pediatric endocrinology · 2015Article
- The Association between Newborn Regional Body Composition and Cord Blood Concentrations of C-Peptide and Insulin-Like Growth Factor I.PloS one · 2015Article
- Prenatal exposure to phenols and growth in boys.Epidemiology (Cambridge, Mass.) · 2014Article
- Specific role of maternal weight change in the first trimester of pregnancy on birth size.Maternal & child nutrition · 2014Article
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Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo understand the relationships between maternal glycemia during pregnancy and prenatal and early postnatal growth by evaluating cord C-peptide and IGF-I as mediating biomarkers in boys and girls separately. RESEARCH DESIGN AND
methodsWe evaluated 342 neonates within the EDEN mother-child cohort study born to mothers without diabetes diagnosis before pregnancy. We measured maternal glycemia at 24-28 weeks of gestation and neonates' cord blood C-peptide (used as a proxy for fetal insulin) and IGF-I at birth. Reported maternal prepregnancy BMI and all measured infant weights and lengths in the 1st year were recorded. Growth modeling was used to obtain an individual growth curve for each infant in the 1st year. Path models, a type of structural equation modeling, were used for statistical analysis. Path analysis is a multivariate method associated with a graphical display that allows evaluation of mediating factors and distinguishes direct, indirect, and total effects.
resultsCord C-peptide at birth was positively correlated with maternal prepregnancy BMI and maternal glycemia and was higher in girls. In a path model that represented prenatal growth, there was no significant direct effect of maternal glycemia on birth weight, but the effect of maternal glycemia on birth weight was mediated by fetal insulin and IGF-I in both girls and boys. However, in girls only, higher concentrations of cord C-peptide (but not cord IGF-I or maternal glucose) were associated with slower weight growth in the first 3 months of life.
conclusionsOur study underlines the role of the fetal insulin-IGF-I axis in the relationship between maternal glycemia during pregnancy and birth weight. We also show for the first time that high insulin concentration in female fetuses is associated with slower early postnatal growth. This slow, early growth pattern may be programmed by fetal hyperinsulinemia, and girls may be more susceptible than boys to its consequences.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.