ArticleJournal of the American Society of Nephrology : JASN2011
Racial and ethnic differences in kidney function decline among persons without chronic kidney disease.
Article in Journal of the American Society of Nephrology : JASN, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
87 citing papers in PubMed, 2 syntheses or guidelines pooled it, 150 citations in OpenAlex.
- Glomerular hyperfiltration defined by eGFR and long-term clinical outcomes: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Examining post-donation outcomes in Hispanic/Latinx living kidney donors in the United States: A systematic review.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Pooled it
- Racial Differences in the Effectiveness of a Multifactorial Telehealth Intervention to Slow Diabetic Kidney Disease.Medical care · 2020Trial
- Determining the effects and challenges of incorporating genetic testing into primary care management of hypertensive patients with African ancestry.Contemporary clinical trials · 2016Trial
- Household Fuel Use and Kidney Disease-Related Mortality: The Golestan Cohort Study.Environmental health perspectives · 2026Article
- Water intake mediates cross-sectional associations between urinary kidney injury biomarkers and race in emerging adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Sex Differences in 6-Year Change in eGFR and ACR in a Multiethnic Population: The HELIUS Study.Kidney medicine · 2026Article
- Frailty, malnutrition risk, and kidney function impairment in older adults: Singapore longitudinal ageing study.GeroScience · 2026Article
- Generalizability of blood-based biomarkers of Alzheimer's disease and related dementias in a multicultural cohort of older adults: The effect of adjustment for kidney function.Journal of Alzheimer's disease : JAD · 2026Article
- Epigenetic aging mediates the association between life course socioeconomic status and decrements in kidney function across a decade.GeroScience · 2026Article
- Global trends and the case of China in Cardio-Kidney-Metabolic multimorbidity: development and validation of a composite risk index using GBD 1990-2021 data.Journal of health, population, and nutrition · 2026Article
- Impact of GST and TP53 gene polymorphisms on susceptibility to end stage renal disease: A case-control analysis.PloS one · 2026Article
- Educational attainment, body mass index, and smoking as mediators in kidney disease risk: a two-step Mendelian randomization study.Renal failure · 2025Article
- Chronic kidney disease in the primary care setting: A narrative review.Journal of general and family medicine · 2025Review
- CKD Knowledge and CKD Report Card Use During a Nephrology Encounter: A Randomized Trial.Kidney medicine · 2025Article
- Association Between Renal Dysfunction and Lipid Ratios in Rural Black South Africans.International journal of environmental research and public health · 2025Article
- Systematic decision frameworks for the socially responsible use of precision medicine.NPJ genomic medicine · 2024Article
- Chronic Kidney Disease in Brazil: Current Status and Recommended Improvements.Kidney diseases (Basel, Switzerland) · 2024Review
- The diabetes cardiovascular outcomes trials and racial and ethnic minority enrollment: impact, barriers, and potential solutions.Frontiers in public health · 2024Review
- Tutorial on model selection and validation of model input into precision dosing software for model-informed precision dosing.CPT: pharmacometrics & systems pharmacology · 2023Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 10 institutions in 1 country.
Funding
Abstract
Whether the rate of kidney function decline before the onset of CKD differs among racial and ethnic groups remains unclear. Here, we evaluated kidney function decline and incident CKD among white, black, Hispanic, and Chinese participants in the Multi-Ethnic Study of Atherosclerosis (MESA) during 5 years of follow-up. We estimated GFR using both cystatin C (eGFRcys) and creatinine (eGFRcreat). The definition of incident CKD required eGFRcys <60 ml/min per 1.73 m(2) and a decline in eGFRcys ≥1 ml/min per year. Among participants with eGFRcreat >60 ml/min per 1.73 m(2) at baseline, blacks had a significantly higher rate of kidney function decline than whites (0.31 ml/min per 1.73 m(2)/yr faster on average, P=0.001), even after adjusting for multiple potential confounders. Among Hispanics, Dominicans and Puerto Ricans had faster rates of decline than whites (0.55 and 0.47 ml/min per 1.73 m(2)/yr faster, respectively). Mexicans, South Americans, or other Hispanics had similar rates of decline compared to whites. We did not detect significant differences in the rates of kidney function decline among Chinese and white participants. Among those with normal or near-normal kidney function at baseline, blacks and Hispanics had the highest rates of incident CKD during follow-up. Adjustment for comorbidities attenuated some of these differences. In conclusion, the average rate of kidney function decline before the onset of CKD differs among racial and ethnic groups. Traditional risk factors do not explain these differences fully, highlighting the need to explore these disparities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.