ArticleMolecular endocrinology (Baltimore, Md.)2011
Impaired FSHbeta expression in the pituitaries of Foxl2 mutant animals.
Article in Molecular endocrinology (Baltimore, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 43 citations in OpenAlex.
- Relationship between Pituitary Gland and Stem Cell in the Aspect of Hormone Production and Disease Prevention: A Narrative Review.Endocrine, metabolic & immune disorders drug targets · 2025Review
- Recent Advances in the Understanding of Gonadotrope Lineage Differentiation in the Developing Pituitary.Neuroendocrinology · 2025Review
- gBLUP-GWAS identifies candidate genes, signaling pathways, and putative functional polymorphisms for age at puberty in gilts.Journal of animal science · 2023Article
- Ovarian Reserve and ART Outcomes in Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Patients WithFrontiers in endocrinology · 2022Article
- Single nucleus multi-omics regulatory landscape of the murine pituitary.Nature communications · 2021Article
- Expression ofAnimals : an open access journal from MDPI · 2019Article
- Molecular regulation of follicle-stimulating hormone synthesis, secretion and action.Journal of molecular endocrinology · 2018Review
- Regulation of reproduction via tight control of gonadotropin hormone levels.Molecular and cellular endocrinology · 2018Review
- FOXL2 modulates cartilage, skeletal development and IGF1-dependent growth in mice.BMC developmental biology · 2015Article
- Minireview: Activin Signaling in Gonadotropes: What Does the FOX say… to the SMAD?Molecular endocrinology (Baltimore, Md.) · 2015Review
- Genetic regulation of murine pituitary development.Journal of molecular endocrinology · 2015Review
- Article
- Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ.Molecular endocrinology (Baltimore, Md.) · 2014Article
- Fox tales: regulation of gonadotropin gene expression by forkhead transcription factors.Molecular and cellular endocrinology · 2014Review
- Follicle-stimulating hormone synthesis and fertility are intact in mice lacking SMAD3 DNA binding activity and SMAD2 in gonadotrope cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Impaired fertility and FSH synthesis in gonadotrope-specific Foxl2 knockout mice.Molecular endocrinology (Baltimore, Md.) · 2013Article
- FOXO1/3 depletion in granulosa cells alters follicle growth, death and regulation of pituitary FSH.Molecular endocrinology (Baltimore, Md.) · 2013Article
- The CpG island in the murine foxl2 proximal promoter is differentially methylated in primary and immortalized cells.PloS one · 2013Article
- Pituitary gland development and disease: from stem cell to hormone production.Current topics in developmental biology · 2013Review
- Cell-type specific modulation of pituitary cells by activin, inhibin and follistatin.Molecular and cellular endocrinology · 2012Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Forkhead box L2 (FoxL2) is required for ovarian development and differentiation. FoxL2 is also expressed in the pituitary where it has been implicated in the development and regulation of gonadotropes, which secrete LH and FSH, the endocrine signals that regulate folliculogenesis in the ovary and spermatogenesis in the testis. Here, we show that FoxL2 is not required for the specification of gonadotropes; the pituitaries of Foxl2 mutant mice contain normal numbers of gonadotropes that express glycoprotein α subunit and LHβ. Whereas the specification of gonadotropes and all other hormonal cell types is normal in the pituitaries of Foxl2 mutant animals, FSHβ levels are severely impaired in both male and female animals, suggesting that FoxL2 is required for normal Fshb expression. The size of the pituitary is reduced in proportion to the smaller body size of Foxl2 mutants, with a concomitant increase in the pituitary cellular density. In primary pituitary cultures, activin induces FSH secretion and Fshb mRNA expression in cells from wild-type mice. In cells from Foxl2 mutant mice, however, FSH secretion is not detected, and activin is unable to drive Fshb expression, suggesting that the mechanism of activin-dependent activation of Fshb transcription is impaired. However, a small number of gonadotropes in the ventromedial region of the pituitaries from Foxl2 mutant mice maintain FSHβ expression, suggesting that a FoxL2- and activin-independent mechanism can drive Fshb transcription. These data indicate that, in addition to its role in the ovary, FoxL2 function in the pituitary is required for normal expression of FSH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.