ArticleNeurology2011
Severity of leukoaraiosis determines clinical phenotype after brain infarction.
Article in Neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- Transcutaneous electrical acupoint stimulation for prevention of postoperative delirium in geriatric patients with silent lacunar infarction: a preliminary study.Clinical interventions in aging · 2018Trial
- White matter hyperintensity determines ischemic stroke severity in symptomatic carotid artery stenosis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- White matter hyperintensity burden in patients with ischemic stroke treated with thrombectomy.Neurology · 2019Article
- Long-range fibre damage in small vessel brain disease affects aphasia severity.Brain : a journal of neurology · 2019Article
- Stroke outcomes are worse with larger leukoaraiosis volumes.Brain : a journal of neurology · 2017Article
- Determinants of white matter hyperintensity burden differ at the extremes of ages of ischemic stroke onset.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2015Article
- Molecular disorganization of axons adjacent to human lacunar infarcts.Brain : a journal of neurology · 2015Article
- Preoperative white matter lesions are independent predictors of long-term survival after internal carotid endarterectomy.Cerebrovascular diseases extra · 2014Article
- Extreme deep white matter hyperintensity volumes are associated with African American race.Cerebrovascular diseases (Basel, Switzerland) · 2014Article
- Clinical neurogenetics: stroke.Neurologic clinics · 2013Review
- Why do stroke patients with negative motor evoked potential show poor limb motor function recovery?Neural regeneration research · 2013Article
- Leukoaraiosis and increased cerebral susceptibility to ischemia: lack of confounding by carotid disease.Journal of the American Heart Association · 2013Article
- Neuroimaging of cerebrovascular disease in the aging brain.Aging and disease · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine whether the extent of leukoaraiosis, a composite marker of baseline brain integrity, differed between patients with TIA with diffusion-weighted imaging (DWI) evidence of infarction (transient symptoms with infarction [TSI]) and patients with ischemic stroke.
methodsLeukoaraiosis volume on MRI was quantified in a consecutive series of 153 TSI and 354 ischemic stroke patients with comparable infarct volumes on DWI. We explored the relationship between leukoaraiosis volume and clinical phenotype (TIA or ischemic stroke) using a logistic regression model.
resultsPatients with TSI tended to be younger (median age 66 vs 69 years, p = 0.062) and had smaller median normalized leukoaraiosis volume (1.2 mL, interquartile range [IQR] 0.2-4.7 mL vs 3.5 mL, IQR 1.2-8.6 mL, p < 0.001). In multivariable analysis controlling for age, stroke risk factors, etiologic stroke mechanism, infarct volume, and infarct location, increasing leukoaraiosis volume remained associated with ischemic stroke (odds ratio 1.05 per mL, 95%confidence interval 1.02-1.09, p = 0.004), along with infarct volume and infarct location.
conclusionThe probability of ischemic stroke rather than TSI increases with increasing leukoaraiosis volume, independent of infarct size and location. Our findings support the concept that the integrity of white matter tracts connecting different parts of the brain could contribute to whether or not patients develop TSI or ischemic stroke in an event of brain infarction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.