ArticleEuropean journal of cell biology2011
A role for Tctex-1 (DYNLT1) in controlling primary cilium length.
Article in European journal of cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 40 citations in OpenAlex.
- m6Am methyltransferase PCIF1 negatively regulates ciliation by inhibiting BICD2 expression.The Journal of cell biology · 2024Article
- Maternal protein deficiency alters primary cilia length in renal tubular and impairs kidney development in fetal rat.Frontiers in nutrition · 2023Article
- LRRK1-mediated NDEL1 phosphorylation promotes cilia disassembly via dynein-2-driven retrograde intraflagellar transport.Journal of cell science · 2022Article
- Consensus nomenclature for dyneins and associated assembly factors.The Journal of cell biology · 2022Article
- Altered mechanotransduction in adolescent idiopathic scoliosis osteoblasts: an exploratory in vitro study.Scientific reports · 2022Article
- Primary cilia: The central role in the electromagnetic field induced bone healing.Frontiers in pharmacology · 2022Review
- CEP55 promotes cilia disassembly through stabilizing Aurora A kinase.The Journal of cell biology · 2021Article
- Tctex-1, a novel interaction partner of Kidney Injury Molecule-1, is required for efferocytosis.Journal of cellular physiology · 2018Article
- Microgravity induces inhibition of osteoblastic differentiation and mineralization through abrogating primary cilia.Scientific reports · 2017Article
- Mechanisms of ciliogenesis suppression in dividing cells.Cellular and molecular life sciences : CMLS · 2017Review
- Microtubule Motors Drive Hedgehog Signaling in Primary Cilia.Trends in cell biology · 2017Review
- The role of the dynein light intermediate chain in retrograde IFT and flagellar function in Chlamydomonas.Molecular biology of the cell · 2016Article
- Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein-Aurora A pathway.The Journal of cell biology · 2016Article
- Cellular Mechanisms of Ciliary Length Control.Cells · 2016Review
- Dynein and intraflagellar transport.Experimental cell research · 2015Review
- Tctex1d2 associates with short-rib polydactyly syndrome proteins and is required for ciliogenesis.Cell cycle (Georgetown, Tex.) · 2015Article
- Subunit composition of the human cytoplasmic dynein-2 complex.Journal of cell science · 2014Article
- Opposing microtubule motors control motility, morphology and cargo segregation during ER-to-Golgi transport.Biology open · 2014Article
- The snRNA-processing complex, Integrator, is required for ciliogenesis and dynein recruitment to the nuclear envelope via distinct mechanisms.Biology open · 2013Article
- A role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2.Journal of cell science · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The microtubule motor complex cytoplasmic dynein is known to be involved in multiple processes including endomembrane organization and trafficking, mitosis, and microtubule organization. The majority of studies of cytoplasmic dynein have focused on the form of the motor that is built around the dynein-1 heavy chain. A second isoform, dynein heavy chain-2, and its specifically associated light intermediate chain, LIC3 (D2LIC), are known to be involved in the formation and function of primary cilia. We have used RNAi in human epithelial cells to define the cytoplasmic dynein subunits that function with dynein heavy chain 2 in primary cilia. We identify the dynein light chain Tctex-1 as a key modulator of cilia length control; depletion of Tctex-1 results in longer cilia as defined by both acetylated tubulin labeling of the axoneme and Rab8a labeling of the cilia membrane. Suppression of dynein heavy chain-2 causes concomitant loss of Tctex-1 and this correlates with an increase in cilia length. Compared to individual depletions, double siRNA depletion of DHC2 and Tctex-1 causes an even greater increase in cilia length. Our data show that Tctex-1 is a key regulator of cilia length and most likely functions as part of dynein-2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.