ArticleJournal of controlled release : official journal of the Controlled Release Society2011
Advanced molecular design of biopolymers for transmucosal and intracellular delivery of chemotherapeutic agents and biological therapeutics.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- In situ radiochemical doping of functionalized inorganic nanoplatforms for theranostic applications: a paradigm shift in nanooncology.Journal of nanobiotechnology · 2025Review
- Nanotechnology-based delivery systems to overcome drug resistance in cancer.Medical review (2021) · 2024Review
- Distributed sensor and actuator networks for closed-loop bioelectronic medicine.Materials today (Kidlington, England) · 2021Article
- Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management.Pharmaceutics · 2021Review
- Soft-Nanoparticle Functionalization of Natural Hydrogels for Tissue Engineering Applications.Advanced healthcare materials · 2019Review
- Cytoplasmic delivery of functional siRNA using pH-Responsive nanoscale hydrogels.International journal of pharmaceutics · 2019Article
- Uptake and function of membrane-destabilizing cationic nanogels for intracellular drug delivery.Bioengineering & translational medicine · 2019Article
- Designing the new generation of intelligent biocompatible carriers for protein and peptide delivery.Acta pharmaceutica Sinica. B · 2018Review
- Cancer nanomedicine: progress, challenges and opportunities.Nature reviews. Cancer · 2017Review
- One-pot synthesis of pH-responsive hybrid nanogel particles for the intracellular delivery of small interfering RNA.Biomaterials · 2016Article
- Hybrid responsive hydrogel carriers for oral delivery of low molecular weight therapeutic agents.Journal of drug delivery science and technology · 2015Article
- New Formulations of Polysaccharide-Based Hydrogels for Drug Release and Tissue Engineering.Gels (Basel, Switzerland) · 2015Review
- Novel PLGA-based nanoparticles for the oral delivery of insulin.International journal of nanomedicine · 2015Article
- Hydrogels and scaffolds for immunomodulation.Advanced materials (Deerfield Beach, Fla.) · 2014Review
- Therapeutic applications of hydrogels in oral drug delivery.Expert opinion on drug delivery · 2014Review
- A review of current nanoparticle and targeting moieties for the delivery of cancer therapeutics.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2013Review
- Expert opinion: Responsive polymer nanoparticles in cancer therapy.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2012Review
- Nanoparticle delivery systems for cancer therapy: advances in clinical and preclinical research.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2012Review
- Amphiphilic Interpenetrating Networks for the Delivery of Hydrophobic, Low Molecular Weight Therapeutic Agents.Industrial & engineering chemistry research · 2011Article
- Responsive theranostic systems: integration of diagnostic imaging agents and responsive controlled release drug delivery carriers.Accounts of chemical research · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Hydrogels have been instrumental in the development of polymeric systems for controlled release of therapeutic agents. These materials are attractive for transmucosal and intracellular drug delivery because of their facile synthesis, inherent biocompatibility, tunable physicochemical properties, and capacity to respond to various physiological stimuli. In this contribution, we outline a multifaceted hydrogel-based approach for expanding the range of therapeutics in oral formulations from classical small-molecule drugs to include proteins, chemotherapeutics, and nucleic acids. Through judicious material selection and careful design of copolymer composition and molecular architecture, we can engineer systems capable of responding to distinct physiological cues, with tunable physicochemical properties that are optimized to load, protect, and deliver valuable macromolecular payloads to their intended site of action. These hydrogel carriers, including complexation hydrogels, tethered hydrogels, interpenetrating networks, nanoscale hydrogels, and hydrogels with decorated structures are investigated for their ability to respond to changes in pH, to load and release insulin and fluorescein, and remain non-toxic to Caco-2 cells. Our results suggest these novel hydrogel networks have great potential for controlled delivery of proteins, chemotherapeutics, and nucleic acids.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.