ArticleJournal of controlled release : official journal of the Controlled Release Society2011
RAFT-synthesized graft copolymers that enhance pH-dependent membrane destabilization and protein circulation times.
Article in Journal of controlled release : official journal of the Controlled Release Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Conjugation of CRAMPInternational journal of molecular sciences · 2024Article
- Polymeric Membranes for Biomedical Applications.Polymers · 2023Review
- A fully automated platform for photoinitiated RAFT polymerization.Digital discovery · 2023Article
- pH-Responsive Amphiphilic Carboxylate Polymers: Design and Potential for Endosomal Escape.Frontiers in chemistry · 2021Review
- Genetically Encoded Split-Luciferase Biosensors to Measure Endosome Disruption Rapidly in Live Cells.ACS sensors · 2020Article
- Polymer nanomedicines.Advanced drug delivery reviews · 2020Review
- Nanotechnology Enabled Modulation of Signaling Pathways Affects Physiologic Responses in Intact Vascular Tissue.Tissue engineering. Part A · 2019Article
- Matrix Metalloproteinase-9-Responsive Nanogels for Proximal Surface Conversion and Activated Cellular Uptake.Biomacromolecules · 2018Article
- Biodistribution Analysis of NIR-Labeled Nanogels Using in Vivo FMT Imaging in Triple Negative Human Mammary Carcinoma Models.Molecular pharmaceutics · 2018Article
- Zwitterionic Nanocarrier Surface Chemistry Improves siRNA Tumor Delivery and Silencing Activity Relative to Polyethylene Glycol.ACS nano · 2017Article
- Polymer nanostructures synthesized by controlled living polymerization for tumor-targeted drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- Dynamic intracellular delivery of antibiotics via pH-responsive polymersomes.Polymer chemistry · 2015Article
- Matrix Metalloproteinase Responsive, Proximity-activated Polymeric Nanoparticles for siRNA Delivery.Advanced functional materials · 2013Article
- Neutral polymeric micelles for RNA delivery.Bioconjugate chemistry · 2013Article
- Macrophage-specific RNA interference targeting via "click", mannosylated polymeric micelles.Molecular pharmaceutics · 2013Article
- Temperature-responsive electrospun nanofibers for 'on-off' switchable release of dextran.Science and technology of advanced materials · 2012Article
- Surface-initiated Polymerization of Azidopropyl Methacrylate and its Film Elaboration via Click Chemistry.Macromolecules · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Here we describe a new graft copolymer architecture of poly(propylacrylic acid) (polyPAA) that displays potent pH-dependent, membrane-destabilizing activity and in addition is shown to enhance protein blood circulation kinetics. PolyPAA containing a single telechelic alkyne functionality was prepared via reversible addition-fragmentation chain transfer (RAFT) polymerization with an alkyne-functional chain transfer agent (CTA) and coupled to RAFT polymerized poly(azidopropyl methacrylate) (polyAPMA) through azide-alkyne [3 + 2] Huisgen cycloaddition. The graft copolymers become membrane destabilizing at endosomal pH values and are active at significantly lower concentrations than the linear polyPAA. A biotin terminated polyPAA graft copolymer was prepared by grafting PAA onto polyAPMA polymerized with a biotin functional RAFT CTA. The blood circulation time and biodistribution of tritium labeled avidin conjugated to the polyPAA graft copolymer was characterized along with a clinically utilized 40kDa branched polyethylene glycol (PEG) also possessing biotin functionalization. The linear and graft polyPAA increase the area under the curve (AUC) over avidin alone by 9 and 12 times, respectively. Furthermore, polyPAA graft copolymer conjugates accumulated in tumor tissue significantly more than the linear polyPAA and the branched PEG conjugates. The collective data presented in this report indicate that the polyPAA graft copolymers exhibit robust pH-dependent membrane-destabilizing activity, low cytotoxicity, significantly enhanced blood circulation time, and increased tumor accumulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.