ArticleClinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association2011
Endoscopic retrograde cholangiography does not reliably distinguish IgG4-associated cholangitis from primary sclerosing cholangitis or cholangiocarcinoma.
Article in Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- [Guidelines on the diagnosis and management of primary sclerosing cholangitis (2021)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Guideline
- Guideline
- Clinical practice guidelines for IgG4-related sclerosing cholangitis.Journal of hepato-biliary-pancreatic sciences · 2019Guideline
- Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in biliary brush cytology.British journal of cancer · 2017Trial
- Anti-integrin αvβ6 autoantibody in primary sclerosing cholangitis: a Japanese nationwide study.Journal of gastroenterology · 2025Article
- IgG4-related disease - focus on digestive system involvement.Frontiers in immunology · 2025Review
- Autoimmune pancreatitis: What we know so far.JGH open : an open access journal of gastroenterology and hepatology · 2022Review
- Endoscopic Evaluation of Biliary Strictures: Current and Emerging Techniques.Clinical endoscopy · 2021Review
- Review of primary sclerosing cholangitis with increased IgG4 levels.World journal of gastroenterology · 2020Review
- Yield of biliary stent cytology: Is it time to think lean?Endoscopy international open · 2019Article
- Rare case of idiopathic sclerosing cholangitis, which was difficult to distinguish from cholangiocarcinoma: A case report.Experimental and therapeutic medicine · 2018Article
- Immunoglobulin G4-related sclerosing cholangitis.The Korean journal of internal medicine · 2018Review
- The Clinicopathologic Spectrum of IgG4-Related DiseaseBalkan medical journal · 2018Article
- Hepatobiliary Manifestations and Complications in Inflammatory Bowel Disease: A Review.Gastroenterology research · 2018Review
- IgG4-Related Sclerosing Cholangitis Involving the Intrahepatic Bile Ducts Diagnosed with Liver Biopsy.Case reports in pathology · 2018Article
- IgG4-related sclerosing cholangitis.Clinical liver disease · 2017Review
- Biliary strictures: endoscopic assessment and management.Frontline gastroenterology · 2017Review
- Development of a scoring system for differentiating IgG4-related sclerosing cholangitis from primary sclerosing cholangitis.Journal of gastroenterology · 2017Article
- Novel biomarkers and endoscopic techniques for diagnosing pancreaticobiliary malignancy.F1000Research · 2017Review
- IgG4-related hepatobiliary disease: an overview.Nature reviews. Gastroenterology & hepatology · 2016Review
Corrections and comments
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Authors and funding
20 authors at 9 institutions in 5 countries.
Funding
Abstract
BACKGROUND &
aimsDistinction of immunoglobulin G4-associated cholangitis (IAC) from primary sclerosing cholangitis (PSC) or cholangiocarcinoma is challenging. We aimed to assess the performance characteristics of endoscopic retrograde cholangiography (ERC) for the diagnosis of IAC.
methodsSeventeen physicians from centers in the United States, Japan, and the United Kingdom, unaware of clinical data, reviewed 40 preselected ERCs of patients with IAC (n = 20), PSC (n = 10), and cholangiocarcinoma (n = 10). The performance characteristics of ERC for IAC diagnosis as well as the κ statistic for intraobserver and interobserver agreement were calculated.
resultsThe overall specificity, sensitivity, and interobserver agreement for the diagnosis of IAC were 88%, 45%, and 0.18, respectively. Reviewer origin, specialty, or years of experience had no statistically significant effect on reporting success. The overall intraobserver agreement was fair (0.74). The operating characteristics of different ERC features for the diagnosis of IAC were poor.
conclusionsDespite high specificity of ERC for diagnosing IAC, sensitivity is poor, suggesting that many patients with IAC may be misdiagnosed with PSC or cholangiocarcinoma. Additional diagnostic strategies are likely to be vital in distinguishing these diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.