ArticleGastroenterology2011
Estrogen regulation of duodenal bicarbonate secretion and sex-specific protection of human duodenum.
Article in Gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 66 citations in OpenAlex.
- The value of melatonin supplementation in postmenopausal women with Helicobacter pylori-associated dyspepsia.BMC women's health · 2020Trial
- Stereoselective Pharmacokinetics of Ketoprofen After Oral Administration of Modified-Release Formulations in Caucasian Healthy Subjects.European journal of drug metabolism and pharmacokinetics · 2016Trial
- Prediction of duodenal ulcers in children withTranslational pediatrics · 2025Article
- Association between menopause, postmenopausal hormone therapy and peptic ulcer disease in Taiwanese population.Scientific reports · 2025Article
- Estrogen regulates duodenal calcium absorption and improves postmenopausal osteoporosis by the effect of ERβ on PMCA1b.Scientific reports · 2025Article
- Genotypic diversity of theJournal of medical microbiology · 2025Article
- The Role of Estrogen across Multiple Disease Mechanisms.Current issues in molecular biology · 2024Review
- SLC26A9 promotes colorectal tumorigenesis by modulating Wnt/β-catenin signaling.Cell death discovery · 2024Article
- Gastrointestinal contrast-enhanced ultrasonography for diagnosis and treatment of peptic ulcer in children.World journal of gastroenterology · 2024Article
- Sex steroid hormones: an overlooked yet fundamental factor in oral homeostasis in humans.Frontiers in endocrinology · 2024Review
- Association Between Serum Bicarbonate Levels and Prediabetes and Subclinical Inflammation in Young Healthy Adults: A Cross-sectional Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Association between the Dietary Inflammatory Index and Gastric Disease Risk: Findings from a Korean Population-Based Cohort Study.Nutrients · 2022Article
- [Upper gastrointestinal ulcer in children: a clinical analysis of 173 cases].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
- Advances in CaExperimental and therapeutic medicine · 2020Review
- Source of dopamine in gastric juice and luminal dopamine-induced duodenal bicarbonate secretion via apical dopamine DBritish journal of pharmacology · 2020Article
- Potential Mechanisms of Age Acceleration Caused by Estrogen Deprivation: Do Endocrine Therapies Carry the Same Risks?JNCI cancer spectrum · 2018Review
- Intracrine Regulation of Estrogen and Other Sex Steroid Levels in Endometrium and Non-gynecological Tissues; Pathology, Physiology, and Drug Discovery.Frontiers in pharmacology · 2018Review
- Estrogen and estrogen receptors in the modulation of gastrointestinal epithelial secretion.Oncotarget · 2017Review
- Melatonin and female hormone secretion in postmenopausal overweight women.International journal of molecular sciences · 2015Article
- Estrogen alleviates acetic acid-induced gastric or colonic damage via both ERα- and ERβ-mediated and direct antioxidant mechanisms in rats.Inflammation · 2014Article
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
BACKGROUND &
aimsThe reason that women have a lower prevalence of duodenal ulcer is not clear. We investigated whether estrogen regulates human duodenal bicarbonate secretion (DBS) and whether this process accounts for sex differences in the prevalence of duodenal ulcer.
methodsWe performed an epidemiologic study to correlate duodenal ulcer prevalence with sex and age. Proximal DBS was measured from healthy subjects. Estrogen-receptor expression was examined in human duodenal mucosa by immunoblot and immunohistochemical analyses.
resultsAmong women, the prevalence of duodenal ulcer was significantly lower than among men. The reduced prevalence was greatest among premenopausal women (20-49 y), who were 3.91- to 5.09-fold less likely to develop duodenal ulcers than age-matched men; the difference was reduced to 1.32-fold or less among subjects aged 60 years or older. Premenopausal (20-29 y), but not postmenopausal (60-69 y), women had significantly higher basal and acid-stimulated DBS than the age-matched men. Basal and acid-stimulated DBS in premenopausal women (20-29 y) were significantly higher than in postmenopausal women (60-69 y), whereas there were no significant differences in basal or acid-stimulated DBS between men who were aged 20-29 years or 60-69 years. Serum levels of estradiol changed in parallel with basal and acid-stimulated DBS during the physiological menstrual cycle in premenopausal women. 17β-estradiol-stimulated DBS was independent of age or sex. Estrogen receptors α and β were detected on plasma membranes and in the cytosol of human duodenal epithelial cells.
conclusionsEstrogen regulates human DBS, which could reduce the risk for duodenal ulcer in women and contribute to sex differences in the prevalence of duodenal ulcer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.