ArticleBreast cancer research : BCR2011
Impact of established prognostic factors and molecular subtype in very young breast cancer patients: pooled analysis of four EORTC randomized controlled trials.
Article in Breast cancer research : BCR, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- The incidence, clinicopathological characteristics and the survival outcomes among young breast cancer patients in Alexandria, Egypt.Ecancermedicalscience · 2026Article
- Clinicopathological characteristics and prognostic outcomes of young adult women (aged 18-30 years) with breast cancer in Ahmedabad, India: a single-centre, retrospective observational study.The Lancet regional health. Southeast Asia · 2025Article
- Clinicopathological prognostic factors for survival in patients with breast cancer: a retrospective study from a tertiary cancer centre from North-West India.Ecancermedicalscience · 2025Article
- Aging and CNS Myeloid Cell Depletion Attenuate Breast Cancer Brain Metastasis.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021Article
- Altona Prognostic Index: A New Prognostic Index for ER-Positive and Her2-Negative Breast Cancer of No Special Type.Cancers · 2021Article
- Conditional Disease-Free and Overall Survival of 1,858 Young Women with Non-Metastatic Breast Cancer and with Participation in a Post-Therapeutic Rehab Programme according to Clinical Subtypes.Breast care (Basel, Switzerland) · 2021Article
- 10-Year Breast Cancer Outcomes in Women ≤35 Years of Age.International journal of radiation oncology, biology, physics · 2021Article
- Personalization in Modern Radiation Oncology: Methods, Results and Pitfalls. Personalized Interventions and Breast Cancer.Frontiers in oncology · 2021Review
- Independent factors FOR poor prognosis in young patients with stage I-III breast cancer.Acta clinica Croatica · 2020Article
- Validation of the 8Aging · 2020Article
- Patterns of Occurrence and Outcomes of Contralateral Breast Cancer: Analysis of SEER Data.Journal of clinical medicine · 2018Article
- Analysis of breast cancer in young women in the Department of Defense (DOD) database.Breast cancer research and treatment · 2018Article
- Article
- MicroRNA-10b expression in node-negative breast cancer-correlation with metastasis and angiogenesis.Oncology letters · 2017Article
- Lymphovascular space invasion and lack of downstaging after neoadjuvant chemotherapy are strong predictors of adverse outcome in young women with locally advanced breast cancer.Cancer medicine · 2016Article
- Correlation of NGX6 expression with clinicopathologic features and prognosis in colon cancer.International journal of clinical and experimental medicine · 2015Article
- Association of ultrasonographic features with NGX6 expression and prognosis in invasive ductal breast carcinoma.International journal of clinical and experimental pathology · 2015Article
- Effects of interval between age at first pregnancy and age at diagnosis on breast cancer survival according to menopausal status: a register-based study in Korea.BMC women's health · 2014Article
- Relationship between chemotherapy and prognosis in different subtypes of node-negative breast cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Breast cancer: Actual methods of treatment and future trends.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2014Review
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6 authors.
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Abstract
introductionYoung age at the time of diagnosis of breast cancer is an independent factor of poor prognosis. In many treatment guidelines, the recommendation is to treat young patients with adjuvant chemotherapy regardless of tumor characteristics. However, limited data on prognostic factors are available for young breast cancer patients. The purpose of this study was to determine the prognostic value of established clinical and pathological prognostic factors in young breast cancer patients.
methodsData from four European Organisation for Research and Treatment of Cancer (EORTC) clinical trials were pooled, resulting in a dataset consisting of 9,938 early breast cancer patients with a median follow-up of 11 years. For 549 patients aged less than 40 years at the time of diagnosis, including 341 node negative patients who did not receive chemotherapy, paraffin tumor blocks were processed for immunohistochemistry using a tissue microarray. Cox proportional hazard analysis was applied to assess the association of clinical and pathological factors with overall and distant metastasis free survival.
resultsFor young patients, tumor size (P = 0.01), nodal status (P = 0.006) and molecular subtype (P = 0.02) were independent prognostic factors for overall survival. In the node negative subgroup, only molecular subtype was a prognostic factor for overall survival (P = 0.02). Young node negative patients bearing luminal A tumors had an overall survival rate of 94% at 10 years' follow-up compared to 72% for patients with basal-type tumors.
conclusionsMolecular subtype is a strong independent prognostic factor in breast cancer patients younger than 40 years of age. These data support the use of established prognostic factors as a diagnostic tool to assess disease outcome and to plan systemic treatment strategies in young breast cancer patients.
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