ArticleVeterinary research2011
Experimental H-type bovine spongiform encephalopathy characterized by plaques and glial- and stellate-type prion protein deposits.
Article in Veterinary research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Bovine Spongiform Encephalopathy: An Integrated Review of Prion Mechanisms, Neuroanatomy, and Control.Veterinary sciences · 2026Review
- Sensitive detection of pathological seeds of α-synuclein, tau and prion protein on solid surfaces.PLoS pathogens · 2024Article
- Discrimination of Classical and Atypical BSE by a Distinct Immunohistochemical PrPPathogens (Basel, Switzerland) · 2023Article
- Differential Accumulation of Misfolded Prion Strains in Natural Hosts of Prion Diseases.Viruses · 2021Review
- Neuropathology of Animal Prion Diseases.Biomolecules · 2021Review
- Article
- Influence of Interspecies Transmission of Atypical Bovine Spongiform Encephalopathy Prions to Hamsters on Prion Characteristics.Frontiers in veterinary science · 2020Article
- Estimation of prion infectivity in tissues of cattle infected with atypical BSE by real time-quaking induced conversion assay.The Journal of veterinary medical science · 2019Article
- Bovine Spongiform Encephalopathy - A Review from the Perspective of Food Safety.Food safety (Tokyo, Japan) · 2019Review
- Animal prion diseases: the risks to human health.Brain pathology (Zurich, Switzerland) · 2019Review
- Deciphering the BSE-type specific cell and tissue tropisms of atypical (H and L) and classical BSE.Prion · 2019Article
- Article
- Atypical BSE: Current Knowledge and Knowledge Gaps.Food safety (Tokyo, Japan) · 2017Review
- Intra- and Interspecies Transmission of Atypical BSE - What Can We Learn from It?Food safety (Tokyo, Japan) · 2016Review
- Coexistence of two forms of disease-associated prion protein in extracerebral tissues of cattle infected with H-type bovine spongiform encephalopathy.The Journal of veterinary medical science · 2016Article
- Emergence of a novel bovine spongiform encephalopathy (BSE) prion from an atypical H-type BSE.Scientific reports · 2016Article
- Detection of Atypical H-Type Bovine Spongiform Encephalopathy and Discrimination of Bovine Prion Strains by Real-Time Quaking-Induced Conversion.Journal of clinical microbiology · 2016Article
- A Comparison of Classical and H-Type Bovine Spongiform Encephalopathy Associated with E211K Prion Protein Polymorphism in Wild-Type and EK211 Cattle Following Intracranial Inoculation.Frontiers in veterinary science · 2016Article
- Transmissibility of H-Type Bovine Spongiform Encephalopathy to Hamster PrP Transgenic Mice.PloS one · 2015Article
- The pathological and molecular but not clinical phenotypes are maintained after second passage of experimental atypical bovine spongiform encephalopathy in cattle.BMC veterinary research · 2014Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atypical bovine spongiform encephalopathy (BSE) has recently been identified in Europe, North America, and Japan. It is classified as H-type and L-type BSE according to the molecular mass of the disease-associated prion protein (Pr(PSc)). To investigate the topographical distribution and deposition patterns of immunolabeled Pr(PSc), H-type BSE isolate was inoculated intracerebrally into cattle. H-type BSE was successfully transmitted to 3 calves, with incubation periods between 500 and 600 days. Moderate to severe spongiform changes were detected in the cerebral and cerebellar cortices, basal ganglia, thalamus, and brainstem. H-type BSE was characterized by the presence of PrP-immunopositive amyloid plaques in the white matter of the cerebrum, basal ganglia, and thalamus. Moreover, intraglial-type immunolabeled Pr(PSc) was prominent throughout the brain. Stellate-type immunolabeled Pr(PSc) was conspicuous in the gray matter of the cerebral cortex, basal ganglia, and thalamus, but not in the brainstem. In addition, Pr(PSc) accumulation was detected in the peripheral nervous tissues, such as trigeminal ganglia, dorsal root ganglia, optic nerve, retina, and neurohypophysis. Cattle are susceptible to H-type BSE with a shorter incubation period, showing distinct and distinguishable phenotypes of Pr(PSc) accumulation.
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