ArticleRespiratory research2011
Expression analysis of asthma candidate genes during human and murine lung development.
Article in Respiratory research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 57 citations in OpenAlex.
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- Translational Analysis of Moderate to Severe Asthma GWAS Signals Into Candidate Causal Genes and Their Functional, Tissue-Dependent and Disease-Related Associations.Frontiers in allergy · 2021Article
- Identification of deleterious and regulatory genomic variations in known asthma loci.Respiratory research · 2018Article
- The Study ofTanaffos · 2018Article
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- Bronchial Epithelial Cells from Asthmatic Patients Display Less Functional HLA-G Isoform Expression.Frontiers in immunology · 2017Article
- Genes associated with polymorphic variants predicting lung function are differentially expressed during human lung development.Respiratory research · 2016Article
- The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro.PloS one · 2016Article
- Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation.Nature communications · 2015Article
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- Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank.The Lancet. Respiratory medicine · 2015Article
- Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures.Molecular autism · 2015Article
- Inflammasome Activity in Non-Microbial Lung Inflammation.Journal of environmental immunology and toxicology · 2014Article
- Characteristic DNA methylation profiles in peripheral blood monocytes are associated with inflammatory phenotypes of asthma.Epigenetics · 2014Article
- Genome-wide association analysis identifies six new loci associated with forced vital capacity.Nature genetics · 2014Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundLittle is known about the role of most asthma susceptibility genes during human lung development. Genetic determinants for normal lung development are not only important early in life, but also for later lung function.
objectiveTo investigate the role of expression patterns of well-defined asthma susceptibility genes during human and murine lung development. We hypothesized that genes influencing normal airways development would be over-represented by genes associated with asthma.
methodsAsthma genes were first identified via comprehensive search of the current literature. Next, we analyzed their expression patterns in the developing human lung during the pseudoglandular (gestational age, 7-16 weeks) and canalicular (17-26 weeks) stages of development, and in the complete developing lung time series of 3 mouse strains: A/J, SW, C57BL6.
resultsIn total, 96 genes with association to asthma in at least two human populations were identified in the literature. Overall, there was no significant over-representation of the asthma genes among genes differentially expressed during lung development, although trends were seen in the human (Odds ratio, OR 1.22, confidence interval, CI 0.90-1.62) and C57BL6 mouse (OR 1.41, CI 0.92-2.11) data. However, differential expression of some asthma genes was consistent in both developing human and murine lung, e.g. NOD1, EDN1, CCL5, RORA and HLA-G. Among the asthma genes identified in genome wide association studies, ROBO1, RORA, HLA-DQB1, IL2RB and PDE10A were differentially expressed during human lung development.
conclusionsOur data provide insight about the role of asthma susceptibility genes during lung development and suggest common mechanisms underlying lung morphogenesis and pathogenesis of respiratory diseases.
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