ReviewCNS drugs2011
Issues in the management of challenging behaviours of adults with autism spectrum disorder.
Review in CNS drugs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Interventions to Improve Outcomes for Parents of Children with Autism Spectrum Disorder: A Meta-Analysis.Journal of autism and developmental disorders · 2022Pooled it
- Psychoeducational Interventions for Adults With Level 3 Autism Spectrum Disorder: A 50-Year Systematic Review.Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2019Pooled it
- Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD).The Cochrane database of systematic reviews · 2016Pooled it
- Aripiprazole for treating irritability in children & adolescents with autism: A systematic review.The Indian journal of medical research · 2015Pooled it
- Current Practices for the Assessment and Treatment of Severe Problem Behavior: A Colorado-Based Survey.Behavior analysis in practice · 2026Article
- Systematic Review of the Efficacy of Parent-Mediated Interventions in Reducing Problem Behaviours Shown by Autistic Adolescents.Journal of autism and developmental disorders · 2026Article
- The Performance-based IISCA Can Inform Effective and Socially Meaningful Skill-based Treatment.Behavior analysis in practice · 2025Article
- The Factor Structure and Validity of the Psychopathy Checklist-Short Version When Used With Autistic Psychiatric Inpatients.Autism research : official journal of the International Society for Autism Research · 2025Article
- Prevalence of Psychotropic Medication Use and Psychotropic Polypharmacy in Autistic Adults With or Without Intellectual Disability.Journal of autism and developmental disorders · 2025Article
- Sedation rates of patients with autism spectrum disorder in the emergency department: a case-matched cohort study.Frontiers in psychiatry · 2025Article
- Cooking for disability: a pilot study on nutritional interventions for mental health support in adults with autism spectrum disorder.Frontiers in psychiatry · 2025Article
- Article
- Pharmacological intervention of behavioural traits and brain histopathology of prenatal valproic acid-induced mouse model of autism.PloS one · 2024Article
- Prevalence of gastrointestinal symptoms among autistic individuals, with and without co-occurring intellectual disability.Autism research : official journal of the International Society for Autism Research · 2023Article
- Understanding the Relationship between Distress Behaviour and Health Status of People with Autism Spectrum Disorder.Healthcare (Basel, Switzerland) · 2023Article
- Autism Spectrum Disorder and collective catering service: results of the pilot study FOOD-AUT.Frontiers in nutrition · 2023Article
- Self-reported impediments at home, school, and community: autistic adults' first-person accounts of their life trajectories and derived pathways.International journal of developmental disabilities · 2022Article
- Adults with Autism: Changes in Understanding Since DSM-111.Journal of autism and developmental disorders · 2021Article
- Association between pica and gastrointestinal symptoms in preschoolers with and without autism spectrum disorder: Study to Explore Early Development.Disability and health journal · 2021Article
- Relationship Among Sensory Over-Responsivity, Problem Behaviors, and Anxiety in Emerging Adults with Autism Spectrum Disorder.Neuropsychiatric disease and treatment · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorder (ASD) is a particularly important risk factor for challenging behaviours such as aggression, tantrums, self-injury and pica. Adults with ASD have rarely been studied with respect to these problems. This is particularly disconcerting since there are far more adults than children with ASD. In addition, because of adults' increased physical size and longer history of these problems, treating these behaviours effectively is important. Psychological methods, particularly applied behaviour analysis, and pharmacotherapy have been the most frequently addressed treatments for challenging behaviours associated with ASD in the research literature. In many cases, challenging behaviours have clear environmental antecedents. In these cases, behavioural interventions, such as applied behaviour analysis, should be used to reduce the behaviours. When environmental factors cannot be identified or when challenging behaviours are very severe, pharmacological treatments may be necessary in combination with behavioural interventions. Newer antipsychotics are the most researched medications for use with this population. Currently, risperidone and aripiprazole are the only medications that have US FDA approval for the treatment of behaviours associated with ASD, specifically irritability; however, they are indicated for use in children not adults. It is important not to use medications unnecessarily, due to possible side effects associated with their use. Based on available research, some recommendations for the treatment of challenging behaviours of adults (and children) with ASD include the use of functional assessment, side-effect monitoring of medications and behavioural methods whenever possible. Additionally, future research in this area needs to focus more on adults, as most current research has used child samples.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.