Evidence map›Paper›PMID 21699263›Full record

ArticleOrganic letters2011

Versatile method for the detection of covalently bound substrates on solid supports by DART mass spectrometry.

Laura M Sanchez, Matthew E Curtis, Bianca E Bracamonte, Kenji L Kurita, Gabriel Navarro, O David Sparkman, Roger G Linington

Abstract read
In one paragraph

Article in Organic letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms.Chemistry (Weinheim an der Bergstrasse, Germany) · 2018
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laura M SanchezDepartment of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California 95064, USA.
Matthew E Curtis
Bianca E Bracamonte
Kenji L Kurita
Gabriel Navarro
O David Sparkman
Roger G Linington

Funding

ICBG: "Training, Conservation and Drug Discovery using Panamanian MicroorganismsU01TW006634 · FIC · SMITHSONIAN INSTITUTION · PI GERWICK, WILLIAM HENRY · 2003 to 2013
$7.8M
Baccalaureate Bridge to the Biomedical Sciences Program (ACCESS)R25GM051765 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CAMARA, JASON N., CREWS, PHIL · 1994 to 2023
$5.6M
FIC NIH HHS U01 TW006634NIGMS NIH HHS GM51765-10NIGMS NIH HHS R25 GM051765
6 · The paper itself

Abstract

Analysis of substrates directly on solid phase resins without the need for separate cleavage conditions remains an outstanding challenge in the field of solid phase synthesis. We now present the first example of simultaneous cleavage and mass spectrometric analysis of peptides from solid supports using direct analysis in real time (DART) mass spectrometry. We have shown that this method is compatible with a diverse array of solid phase resins and is suitable for analysis of both peptides and organic substrates.

Indexed as

Amino AcidsMass SpectrometryMolecular StructurePeptidesAmino AcidsPeptides

Identifiers

PMID21699263
PMCPMC3146587

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.