ArticleMedical microbiology and immunology2012
Neurocysticercosis: local and systemic immune-inflammatory features related to severity.
Article in Medical microbiology and immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Efficiency of Cysticidal Therapy Impacted by the Host's Immune Response in Neurocysticercosis Patients.Molecular neurobiology · 2025Article
- Helminthic larval stage induces cellular apoptosis via caspase 9-mediated mitochondrial dysfunction.Frontiers in immunology · 2025Article
- Evaluating the modulation of peripheral immune profile in people living with HIV and (Neuro)cysticercosis.PLoS neglected tropical diseases · 2024Article
- The role of helminths in the development of non-communicable diseases.Frontiers in immunology · 2022Review
- The Local Inflammatory Profile and Predictors of Treatment Success in Subarachnoid Neurocysticercosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Host immune responses during Taenia solium Neurocysticercosis infection and treatment.PLoS neglected tropical diseases · 2020Review
- Etanercept to Control Inflammation in the Treatment of Complicated Neurocysticercosis.The American journal of tropical medicine and hygiene · 2019Observational
- TNF-α blockade suppresses pericystic inflammation following anthelmintic treatment in porcine neurocysticercosis.PLoS neglected tropical diseases · 2017Article
- Effect of Transforming Growth Factor-β upon Taenia solium and Taenia crassiceps Cysticerci.Scientific reports · 2017Article
- Post-treatment vascular leakage and inflammatory responses around brain cysts in porcine neurocysticercosis.PLoS neglected tropical diseases · 2015Article
- Neurocysticercosis: the effectiveness of the cysticidal treatment could be influenced by the host immunity.Medical microbiology and immunology · 2014Article
- Annotation of the transcriptome from Taenia pisiformis and its comparative analysis with three Taeniidae species.PloS one · 2012Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurocysticercosis (NC) is caused by the establishment of Taenia solium cysticerci in the central nervous system. Previous studies have established that neuroinflammation plays a key role in the severity of the disease. However, the relationship between peripheral and local immune response remains inconclusive. This work studies the peripheral and local immune-inflammatory features and their relationships, toward the identification of potential peripheral immunologic features related to severity. A panel of cytokines was measured in paired cerebrospinal fluid (CSF) and in the supernatant of antigen-specific stimulated peripheral blood mononuclear cells samples (SN) in a total of 31 untreated inflammatory and non-inflammatory NC patients. Increased clinical and radiologic severity was associated with an increased cerebrospinal fluid cell count. A peripheral proliferative depression that negatively correlates with CSF cellularity and TNFα and that positively correlates with SN IL5 was observed in severe NC patients. These results provide evidences to support the systemic proliferative response as a biomarker to monitor the level of neuroinflammation, of possible value in the patients' follow-up during treatment.
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